发明公开
EP0229370A1 Guanidinobenzoic ester derivative, a process for preparing same and pharmaceutical compositions containing same
失效
Guanidinobenzoesäureesterderivate，其制备方法以及含有它们的药物组合物的方法。
- 专利标题： Guanidinobenzoic ester derivative, a process for preparing same and pharmaceutical compositions containing same
- 专利标题（中）： Guanidinobenzoesäureesterderivate，其制备方法以及含有它们的药物组合物的方法。
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申请号： EP86117885.3申请日： 1986-12-22
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公开(公告)号： EP0229370A1公开(公告)日： 1987-07-22
- 发明人: Souda, Shigeru , Shimomura, Naoyuki , Ueda, Norihiro , Miyazawa, Shuhei , Yamanaka, Takashi , Miyamoto, Kaname , Hishinuma, Ieharu , Nagakawa, Junichi , Nagaoka, Naoko , Kawashima, Hidetoshi , Kawata, Tsutomu , Nagaoka, Junsaku , Wakabayashi, Tsuneo
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112 JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112 JP
- 代理机构： Hansen, Bernd, Dr.rer.nat.
- 优先权： JP293268/85 19851227
- 主分类号： C07C149/437
- IPC分类号： C07C149/437 ; C07D207/404 ; C07D209/48 ; C07D263/44 ; A61K31/245 ; A61K31/40 ; A61K31/42
摘要：
A guanidinobenzoic ester derivative having the formula
wherein X represents a group of the formula:
in which Y is a group of the formula:
-(CH₂) m -, m being an integer of 2 or 3,
or a group of the formula:
-OR
in which R is a hydrogen atom or a lower alkyl group, and n represents an integer of l to 5,
which is effective to inhibit enzymes such as trypsin, plasmin and thrombin and useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis is disclosed as well as a process for preparing same and a pharmaceutical composition containing same.
wherein X represents a group of the formula:
in which Y is a group of the formula:
-(CH₂) m -, m being an integer of 2 or 3,
or a group of the formula:
-OR
in which R is a hydrogen atom or a lower alkyl group, and n represents an integer of l to 5,
which is effective to inhibit enzymes such as trypsin, plasmin and thrombin and useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis is disclosed as well as a process for preparing same and a pharmaceutical composition containing same.
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