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1.发明公开Guanidinobenzoic ester derivative, a process for preparing same and pharmaceutical compositions containing same 失效Guanidinobenzoesäureesterderivate，其制备方法以及含有它们的药物组合物的方法。
公开(公告)号：EP0229370A1
公开(公告)日：1987-07-22
申请号：EP86117885.3
申请日：1986-12-22
申请人： Eisai Co., Ltd.
发明人： Souda, Shigeru , Shimomura, Naoyuki , Ueda, Norihiro , Miyazawa, Shuhei , Yamanaka, Takashi , Miyamoto, Kaname , Hishinuma, Ieharu , Nagakawa, Junichi , Nagaoka, Naoko , Kawashima, Hidetoshi , Kawata, Tsutomu , Nagaoka, Junsaku , Wakabayashi, Tsuneo
IPC分类号： C07C149/437 , C07D207/404 , C07D209/48 , C07D263/44 , A61K31/245 , A61K31/40 , A61K31/42
CPC分类号： C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
摘要： A guanidinobenzoic ester derivative having the formula
wherein X represents a group of the formula:
in which Y is a group of the formula:
-(CH₂) m -, m being an integer of 2 or 3,
or a group of the formula:
-OR
in which R is a hydrogen atom or a lower alkyl group, and n represents an integer of l to 5,
which is effective to inhibit enzymes such as trypsin, plasmin and thrombin and useful for treatment of the pancreatitis and hemorrhagic disease and thrombosis is disclosed as well as a process for preparing same and a pharmaceutical composition containing same.-
公开(公告)号：EP0436911A3
公开(公告)日：1991-07-24
申请号：EP90125193.4
申请日：1990-12-21
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Hamamura, Kimio , Nakamura, Takaharu , Ema, Kiiti , Banba, Takashi , Nakamura, Tetsuya , Kawashima, Hidetoshi , Inai, Yuuichi , Sano, Noritoshi , Miyauchi, Yuko , Kijima, Shizumasa
IPC分类号： C07D405/12 , A61K31/455 , C07D311/72 , C07D405/14
CPC分类号： C07D405/14
摘要： The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I):
wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m-
3.发明公开Novel vitamin E derivatives and process for the production thereof 失效维生素E衍生物和Verfahren zu deren Herstellung。
公开(公告)号：EP0436911A2
公开(公告)日：1991-07-17
申请号：EP90125193.4
申请日：1990-12-21
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Hamamura, Kimio , Nakamura, Takaharu , Ema, Kiiti , Banba, Takashi , Nakamura, Tetsuya , Kawashima, Hidetoshi , Inai, Yuuichi , Sano, Noritoshi , Miyauchi, Yuko , Kijima, Shizumasa
IPC分类号： C07D405/12 , A61K31/455 , C07D311/72 , C07D405/14
CPC分类号： C07D405/14
摘要： The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I):
wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m摘要翻译： 新型维生素E衍生物提供优异的抗高脂血症作用，并由式（I）定义：
其中R表示烟酰基; 并且m是2至5的整数，而n是3至6的整数，条件是n大于m < -
4.发明授权Guanidinobenzoic ester derivative, a process for preparing same and pharmaceutical compositions containing same 失效胍基苯甲酸衍生物，其制备方法和含有其的药物组合物
公开(公告)号：EP0229370B1
公开(公告)日：1989-04-19
申请号：EP86117885.3
申请日：1986-12-22
申请人： Eisai Co., Ltd.
发明人： Souda, Shigeru , Shimomura, Naoyuki , Ueda, Norihiro , Miyazawa, Shuhei , Yamanaka, Takashi , Miyamoto, Kaname , Hishinuma, Ieharu , Nagakawa, Junichi , Nagaoka, Naoko , Kawashima, Hidetoshi , Kawata, Tsutomu , Nagaoka, Junsaku , Wakabayashi, Tsuneo
IPC分类号： C07C149/437 , C07D207/404 , C07D209/48 , C07D263/44 , A61K31/245 , A61K31/40 , A61K31/42
CPC分类号： C07D207/404 , C07C323/20 , C07D209/48 , C07D263/44
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5.发明授权Carboximide derivatives, process for their production and medicines containing same 失效碳酰亚胺衍生物，其生产方法及含有其的药物
公开(公告)号：EP0111226B1
公开(公告)日：1987-09-16
申请号：EP83111830.2
申请日：1983-11-25
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Souda, Shigeru , Miyake, Kazutoshi , Kuriyama, Shizuo , Usuki, Kazuyasu , Akiyama, Yasuhiro , Nagaoka, Naoko , Kawashima, Hidetoshi
IPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12 , A61K31/40
CPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12
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6.发明公开Carboximide derivatives, process for their production and medicines containing same 失效甲酰亚胺衍生物，含有它们的制备方法和药物。
公开(公告)号：EP0111226A1
公开(公告)日：1984-06-20
申请号：EP83111830.2
申请日：1983-11-25
申请人： Eisai Co., Ltd.
发明人： Hirose, Noriyasu , Souda, Shigeru , Miyake, Kazutoshi , Kuriyama, Shizuo , Usuki, Kazuyasu , Akiyama, Yasuhiro , Nagaoka, Naoko , Kawashima, Hidetoshi
IPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12 , A61K31/40
CPC分类号： C07D209/48 , C07D209/76 , C07D401/12 , C07D403/12
摘要： A carboximide derivative represented by the general formula:
wherein X is
Z is alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkenyl or arylalkenyl, and Y is a substituted or unsubstituted pyridyl, pyrimidyl or phenyl group, and a pharmaceutically acceptable acid addition salt thereof. The carboximide derivative and acid addition salt are useful for treating diabetes and also for depressing the central nervous system. The carboximide derivative may be produced by reacting a sodium alkoxide represented by the general formula:
wherein X and Y have the same meanings as defined above, with Z·Hal wherein Hal is a halogen and Z has the same meaning as defined above.
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