发明公开
- 专利标题： PYRAZOLOPYRIMIDINES, INTERMEDIATES THEREOF AND PROCESSES FOR THE PREPARATION OF THEM
- 专利标题（中）： 吡唑并嘧啶，其中间体及其制备方法
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申请号： EP87102392申请日： 1987-02-19
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公开(公告)号： EP0234514A3公开(公告)日： 1988-10-19
- 发明人: FUJIKAWA, YOSHIHIRO NISSAN CHEM. IND. LTD. , WAKAMATSU, MASAZUMI NISSAN CHEM. IND. LTD. , FUKUI, MARIKO , MIYASAKA, TADASHI
- 申请人： NISSAN CHEMICAL INDUSTRIES LTD.
- 专利权人： NISSAN CHEMICAL INDUSTRIES LTD.
- 当前专利权人： NISSAN CHEMICAL INDUSTRIES LTD.
- 优先权： JP3432086 1986-02-19
- 主分类号： C07D231/48
- IPC分类号： C07D231/48 ; C07D487/04 ; C07D231/46
摘要：
Disclosed is a process for preparing a 3-hydroxy-7- mercaptopyrazolo[4,3-d]pyrimidine compound represented by the general formula (IX): wherein R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group, which comprises:
from a pyrazole compound represented by the general formula (III): wherein R¹ is the same as defined above.
Also disclosed are pyrazole compounds represented by the general formula (I): wherein:
R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atom, a phenyl group or a substituted phenyl group:
X is a nitroso group, an amino group or (R²)₂NCH=N- (wherein R² is an alkyl group having l to 3 carbon atoms): and
Y is -C(O)NH₂ when R¹ is an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is a nitroso group, or -C(O)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is an amino group, or CN or -C(S)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is (R²)₂NCH=N- (wherein R² is the same as defined above. The compounds serve as intermediate for preparing the compound of the formula (IX).
from a pyrazole compound represented by the general formula (III): wherein R¹ is the same as defined above.
Also disclosed are pyrazole compounds represented by the general formula (I): wherein:
R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atom, a phenyl group or a substituted phenyl group:
X is a nitroso group, an amino group or (R²)₂NCH=N- (wherein R² is an alkyl group having l to 3 carbon atoms): and
Y is -C(O)NH₂ when R¹ is an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is a nitroso group, or -C(O)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is an amino group, or CN or -C(S)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is (R²)₂NCH=N- (wherein R² is the same as defined above. The compounds serve as intermediate for preparing the compound of the formula (IX).
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