公开(公告)号：EP0234514A3

公开(公告)日：1988-10-19

申请号：EP87102392

申请日：1987-02-19

申请人： NISSAN CHEMICAL INDUSTRIES LTD.

发明人： FUJIKAWA, YOSHIHIRO NISSAN CHEM. IND. LTD. ,  WAKAMATSU, MASAZUMI NISSAN CHEM. IND. LTD. ,  FUKUI, MARIKO ,  MIYASAKA, TADASHI

IPC分类号： C07D231/48 ,  C07D487/04 ,  C07D231/46

CPC分类号： C07D487/04 ,  C07D231/48

摘要： Disclosed is a process for preparing a 3-hydroxy-7-­ mercaptopyrazolo[4,3-d]pyrimidine compound represented by the general formula (IX): wherein R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group, which comprises:
    from a pyrazole compound represented by the general formula (III): wherein R¹ is the same as defined above.
Also disclosed are pyrazole compounds represented by the general formula (I): wherein:
    R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atom, a phenyl group or a substituted phenyl group:
    X is a nitroso group, an amino group or (R²)₂NCH=N- ­ (wherein R² is an alkyl group having l to 3 carbon atoms): and
    Y is -C(O)NH₂ when R¹ is an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is a nitroso group, or -C(O)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is an amino group, or CN or -C(S)NH₂ when R¹ is a hydrogen atom, an alkyl group having l to 4 carbon atoms, a phenyl group or a substituted phenyl group and X is (R²)₂NCH=N- (wherein R² is the same as defined above. The compounds serve as intermediate for preparing the compound of the formula (IX).