发明公开
- 专利标题： Synthesis of azetidinones
- 专利标题（中）： Synthese von Azetidinonen。
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申请号： EP87306402.6申请日： 1987-07-20
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公开(公告)号： EP0255278A1公开(公告)日： 1988-02-03
- 发明人: Hou, Donald Chen-Tung , Wong, Yee-Shing , Gala, Dinesh , Steinman, Martin
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth New Jersey 07033 US
- 代理机构： Ritter, Stephen David
- 优先权： US887394 19860721
- 主分类号： C07F7/18
- IPC分类号： C07F7/18 ; C07D205/08 ; C07D499/00
摘要：
A process for producing a compound having the formula
wherein Pr is hydrogen or a hydroxy protecting group and Pr¹ is a carboxy protecting group, comprising reacting a compound of the formula
wherein Pr is as previously defined, with a compound having the formula Pr¹-OH, wherein Pr¹ is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula:
wherein L is a leaving group.
Three reaction schemes are disclosed as well as novel intermediate compounds.
wherein Pr is hydrogen or a hydroxy protecting group and Pr¹ is a carboxy protecting group, comprising reacting a compound of the formula
wherein Pr is as previously defined, with a compound having the formula Pr¹-OH, wherein Pr¹ is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula:
wherein L is a leaving group.
Three reaction schemes are disclosed as well as novel intermediate compounds.
公开/授权文献
- EP0255278B1 Synthesis of azetidinones 公开/授权日：1992-03-11
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