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11 条记录 (耗时 0.011 秒)

    Preparation of chiral hydroxyketones
    3.
    发明公开
    Preparation of chiral hydroxyketones 失效
    Herstellung von chiralen Hydroxyketonen。

    公开(公告)号：EP0506341A1

    公开(公告)日：1992-09-30

    申请号：EP92302534.0

    申请日：1992-03-25

    申请人： SCHERING CORPORATION

    发明人： Gala, Dinesh

    IPC分类号： C07C45/64 ,  C07C49/807 ,  C07C49/82 ,  C07C45/46

    CPC分类号： C07D309/12 ,  C07C45/46 ,  C07C45/64 ,  C07C49/807 ,  C07C49/82

    摘要： A process for preparing an hydroxyketone of the formula (X):

    wherein Ar represents substituted phenyl, aromatic heterocyclic, or substituted aromatic heterocyclic; R 1 and R 2 independently represents hydrogen, C-1 to C-16 alkyl, aromatic, substituted aromatic, aromatic heterocyclic, substituted aromatic heterocyclic or C-1 to C-5 alkyl covalently bonded to Ar, with the provision that R 1 and R 2 are different. The process comprises contacting a compound of the formula (V):

    with a solvent, a base and a chiral hydroxylating agent at a temperature of about -85°C or less.
    Compounds of the formulae


    also are disclosed.

    摘要翻译： 制备式（X）的羟基酮的方法：其中Ar表示取代的苯基，芳族杂环或取代的芳族杂环; R 1和R 2独立地表示氢，C 1至C 16烷基，芳族，取代的芳族，芳族杂环，取代的芳族杂环或与Ar共价结合的C-1至C-5烷基， R 1和R 2不同。 该方法包括在约-85℃或更低的温度下使式（V）化合物：与溶剂，碱和手性羟基化试剂接触。 也公开了式的化合物。

    Synthesis of azetidinones
    7.
    发明公开
    Synthesis of azetidinones 失效
    Synthese von Azetidinonen。

    公开(公告)号：EP0255278A1

    公开(公告)日：1988-02-03

    申请号：EP87306402.6

    申请日：1987-07-20

    申请人： SCHERING CORPORATION

    发明人： Hou, Donald Chen-Tung ,  Wong, Yee-Shing ,  Gala, Dinesh ,  Steinman, Martin

    IPC分类号： C07F7/18 ,  C07D205/08 ,  C07D499/00

    CPC分类号： C07F7/186 ,  C07D205/09 ,  C07D499/88 ,  Y02P20/55

    摘要： A process for producing a compound having the formula
    wherein Pr is hydrogen or a hydroxy protecting group and Pr¹ is a carboxy protecting group, comprising reacting a compound of the formula
    wherein Pr is as previously defined, with a compound having the formula Pr¹-OH, wherein Pr¹ is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula:
    wherein L is a leaving group.
    Three reaction schemes are disclosed as well as novel intermediate compounds.

    摘要翻译： 一种制备具有式CHEM的化合物的方法，其中Pr是氢或羟基保护基，Pr 1是羧基保护基，其包括使式（CHEM）化合物（其中Pr如前所定义）与 具有式Pr 1 -OH的化合物，其中Pr 1如前所定义，无机酸或有机碱的银盐，并使所得产物与具有下式的化合物反应： 其中L是离去基团。 公开了三种反应方案以及新的中间体化合物。