- 专利标题： IMPROVED PROCESS FOR THE PREPARATION OF TETRACYCLINE DERIVATIVES
- 专利标题（中）： 用于生产四环素。
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申请号： EP88908310.0申请日： 1988-09-16
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公开(公告)号： EP0331708A1公开(公告)日： 1989-09-13
- 发明人: SZALAY, Erzsébet , LUGOSI, György , KALLAY, U., Tamás , NAD, Zsuzsanna , JELINEK, István , SIMONIDESZ, Vilmos , GYORI, Péter , NAGY, Lajos , LUGOSI, Márta , SANTANE SINGOLA, Ilona , BESENYI, Gábor , SIMANDI, Lászl(RTM)
- 申请人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.
- 申请人地址： To utca 1-5 H-1045 Budapest IV HU
- 专利权人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.
- 当前专利权人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.
- 当前专利权人地址： To utca 1-5 H-1045 Budapest IV HU
- 代理机构： Skailes, Humphrey John, et al
- 优先权： HU19870004164 19870918
- 国际公布： WO1989002429 19890323
- 主分类号： B01J27
- IPC分类号： B01J27 ; C07B61 ; C07C231 ; C07C233 ; C07C237 ; C07D237
摘要：
The invention relates to a process for the preparation of tetracycline derivatives of formula (I), and acid addition salts thereof, wherein R stands for -CH₃ or = CH₂, by dehalogen ating and hy drating chloromethacycline or acid addition salt thereof of formula (II), or by hydrating methacycline or acid addition salts thereof of formula (III), by a treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises perform ing hydrating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and sele nium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if de sired dehalogenation and hydration in one step.
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