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公开(公告)号:EP4442363A1
公开(公告)日:2024-10-09
申请号:EP22901288.5
申请日:2022-11-29
发明人: OKUMURA, Shigeki , KAGAWA, Tsukasa , YASUDA, Shogo
IPC分类号: B01J23/887 , B01J35/10 , C07B61/00 , C07C45/35 , C07C47/22
CPC分类号: C07C47/22 , B01J23/887 , C07C45/35 , C07B61/00 , B01J35/60
摘要: The present invention relates to a catalyst having at least one peak in each of a range of a pore diameter of 0.45 µm to 10.0 µm and a range of a pore diameter of 0.040 µm to 0.45 µm in a pore distribution (-dV/d (log D) vs D) measured by mercury porosimetry, in which when a maximum value of -dV/d (log D) in the range of the pore diameter of 0.45 µm to 10.0 µm is represented by A and a maximum value of -dV/d (log D) in the range of the pore diameter of 0.040 µm to 0.45 µm is represented by B, (B/A) is 0.20 to 13.0 (V represents a volume (unit: mL/g) of filled mercury per sample weight, D represents the pore diameter (unit: µm), log D represents a natural logarithm of D, and -dV/d (log D) represents a reciprocal of a value obtained by differentiating a cumulative pore volume in a specific pore diameter range by a logarithm of the pore diameter).
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公开(公告)号:EP4442362A1
公开(公告)日:2024-10-09
申请号:EP22901287.7
申请日:2022-11-29
发明人: KAGAWA, Tsukasa , OKUMURA, Shigeki , YASUDA, Shogo
IPC分类号: B01J23/887 , B01J35/10 , C07B61/00 , C07C45/35 , C07C47/22
CPC分类号: C07C47/22 , B01J23/887 , C07C45/35 , C07B61/00 , B01J35/60
摘要: The present invention relates to a catalyst in which a ratio (B/A) of a cumulative pore volume (B) in a pore diameter of 0.35 µm to 4.0 µm to a cumulative pore volume (A) in a pore diameter of 4.0 µm to 10.0 µm measured by mercury porosimetry is 2.5 to 15.0, and a cumulative specific surface area is less than 5 m2/g.
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公开(公告)号:EP4414374A1
公开(公告)日:2024-08-14
申请号:EP22916092.4
申请日:2022-12-27
IPC分类号: C07K1/02 , C07B61/00 , C07C227/18 , A61K38/12 , A61P35/00 , C07C229/00 , C07K7/64
CPC分类号: Y02P20/55 , A61K38/12 , A61P35/00 , C07B61/00 , C07C227/18 , C07C229/00 , C07K1/02 , C07K7/64
摘要: Provided is a method for producing an N-monoalkylamino acid or an ester thereof or a peptide containing the N-monoalkylamino acid or an ester thereof, the method comprising an alkylation step of mixing a starting amino acid or an ester thereof or a peptide containing the starting amino acid or an ester thereof, a C1-C6 primary alkylating agent or a substituted methyl halide, and a catalyst in a solvent in the presence of hydrogen, wherein the alkylation step is carried out at a pressure of 1 atm or more, and produces an N-monoalkylamino acid or an ester thereof or a peptide containing the N-monoalkylamino acid or an ester thereof in which a primary alkyl group corresponding to the C1-C6 primary alkylating agent or the substituted methyl halide is attached to an amino group of the starting amino acid or an ester thereof.
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公开(公告)号:EP4414350A1
公开(公告)日:2024-08-14
申请号:EP22878241.3
申请日:2022-09-01
申请人: Resonac Corporation
IPC分类号: C07C17/358 , B01J23/04 , C07B37/08 , C07B61/00 , C07C21/18
CPC分类号: C07C17/358 , C07C21/18 , C07B37/08 , B01J23/04 , C07B61/00
摘要: Provided is a method capable of producing (E)-1,1,1,4,4,4-hexafluoro-2-butene at a high yield even with a catalyst containing alumina having a large sodium content. The method for producing (E)-1,1,1,4,4,4-hexafluoro-2-butene includes an isomerization step of bringing (Z)-1,1,1,4,4,4-hexafluoro-2-butene into contact with a catalyst containing alumina to isomerize the (Z)-1,1,1,4,4,4-hexafluoro-2-butene to (E)-1,1,1,4,4,4-hexafluoro-2-butene. The alumina is a porous body having a plurality of pores and having a central pore size of 5 nm or more and 40 nm or less. The proportion of the total volume of pores having a pore size of not less than -50% and not more than +50% of the central pore size, of all the pores of the porous body, to the total pore volume of the porous body is 70% or more.
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公开(公告)号:EP4410769A1
公开(公告)日:2024-08-07
申请号:EP22876507.9
申请日:2022-09-29
IPC分类号: C07C45/85 , C07B61/00 , C07C45/36 , C07C49/675
摘要: Provided is a method for producing fluorenone comprising an oxidation step of oxidizing fluorene in the presence of an aliphatic carboxylic acid having 2 to 3 carbon atoms, a metal catalyst, a bromine compound, and oxygen, and a phosphoric acid treatment step of bringing an oxidation reaction mixture into contact with phosphoric acid in the order indicated.
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公开(公告)号:EP4410765A1
公开(公告)日:2024-08-07
申请号:EP22875619.3
申请日:2022-08-10
申请人: Resonac Corporation
IPC分类号: C07C17/25 , B01J27/132 , C07C17/20 , C07C21/18 , C07B61/00
CPC分类号: C07C17/25 , C07C21/18 , B01J27/132 , C07C17/20 , C07B61/00
摘要: Provided is a method capable of producing (E)-1,1,1,4,4,4-hexafluoro-2-butene at a high yield. The method for producing (E)-1,1,1,4,4,4-hexafluoro-2-butene includes vaporizing 1,2,3,4-tetrachlorobutane and reacting the 1,2,3,4-tetrachlorobutane vaporized in the vaporizing, with chlorine gas and hydrogen fluoride gas in the gas phase in the presence of a solid catalyst to yield (E)-1,1,1,4,4,4-hexafluoro-2-butene.
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公开(公告)号:EP3943477B1
公开(公告)日:2024-08-07
申请号:EP20774712.2
申请日:2020-03-17
IPC分类号: C07C45/45 , C07C45/61 , C07C49/385 , C07C49/413 , C07C49/587 , C07B61/00 , C07C49/647 , C07C41/01 , C07C41/56 , C07C45/51
CPC分类号: C07C41/01 , C07C2601/2020170501 , C07C41/56 , C07C45/513 , C07C45/515
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公开(公告)号:EP3868763B1
公开(公告)日:2024-07-03
申请号:EP19872746.3
申请日:2019-10-07
IPC分类号: C07D487/08 , C07B61/00 , C01B39/48 , B01J23/648 , B01J27/18 , B01J23/652
CPC分类号: C07D487/08 , C01B39/48 , B01J23/6482 , B01J23/6525 , B01J27/1806
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公开(公告)号:EP4375273A1
公开(公告)日:2024-05-29
申请号:EP22845947.5
申请日:2022-07-20
发明人: KUWATA Kazuaki , SOMEYA Hidehisa
IPC分类号: C07D213/76 , A61K31/44 , A61K31/4436 , A61P35/00 , B01J31/22 , B01J31/24 , C07B61/00 , C07D213/73 , C07D333/66 , C07D409/12
CPC分类号: A61K31/4436 , A61K31/44 , A61P35/00 , B01J31/24 , B01J31/22 , C07B61/00 , C07D213/73 , C07D213/76 , C07D333/66 , C07D409/12
摘要: The present disclosure provides, for example, a method for producing 2-(4-cyclopropyl-2-fluoroanilino)-3,4-difluoro-5-[[3-fluoro-2-(methylsu lfamoylamino)pyridin-4-yl]methyl]benzamide or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt, the method comprising reacting (2-amino-3-fluoropyridin-4-yl)methanol with methyl chloroformate and N,N-dimethylaminopyridine in acetonitrile to give (2-amino-3-fluoropyridin-4-yl)methyl methyl carbonate. According to the present disclosure, there is provided a method for producing a specific aryl amide derivative that has RAF/MEK complex-stabilizing activity and/or MEK-inhibiting activity and is useful for the treatment or prevention of a cell proliferative disorder, particularly a cancer, the method enabling the aryl amide derivative to be produced with a small number of steps.
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公开(公告)号:EP3769838B1
公开(公告)日:2024-05-22
申请号:EP19772527.8
申请日:2019-03-22
IPC分类号: B01J23/887 , B01J23/00 , B01J35/08 , B01J35/10 , B01J37/00 , B01J37/08 , C07C45/35 , C07C47/22 , C07C51/25 , C07C57/05 , C07B61/00
CPC分类号: C07C45/35 , C07B61/00 , C07C51/252 , B01J37/0045 , B01J37/0036 , B01J37/088 , B01J23/8876 , B01J37/0063 , B01J2523/0020130101 , B01J23/002 , B01J35/60 , B01J35/633
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