专利检索 ap:("CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.") AND inv:"KALLAY, U., Tamás" 第 1 页

1.

发明授权
IMPROVED PROCESS FOR THE PREPARATION OF TETRACYCLINE DERIVATIVES 失效
标题翻译：改进四环素衍生物的制备方法

公开(公告)号：EP0331708B1

公开(公告)日：1993-05-12

申请号：EP88908310.1

申请日：1988-09-16

申请人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

发明人： SZALAY, Erzsébet , LUGOSI, György , KALLAY, U., Tamás , NAD, Zsuzsanna , JELINEK, István , SIMONIDESZ, Vilmos , GYORI, Péter , NAGY, Lajos , LUGOSI, Márta , SANTANE SINGOLA, Ilona , BESENYI, Gábor , SIMANDI, Lászlo

IPC分类号： C07C237/26 , B01J27/057

CPC分类号： C07C233/00

摘要： The invention relates to a process for the preparation of tetracycline derivatives of formula (I), and acid addition salts thereof, wherein R stands for -CH3 or =CH2, by dehalogenating and hy drating chloromethacycline or acid addition salt thereof of formula (II), or by hydrating methacycline or acid addition salts thereof of formula (III), by a treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing hydrating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydration in one step.

2.

发明公开
IMPROVED PROCESS FOR THE PREPARATION OF TETRACYCLINE DERIVATIVES 失效
标题翻译：用于生产四环素。

公开(公告)号：EP0331708A1

公开(公告)日：1989-09-13

申请号：EP88908310.0

申请日：1988-09-16

申请人： CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT.

发明人： SZALAY, Erzsébet , LUGOSI, György , KALLAY, U., Tamás , NAD, Zsuzsanna , JELINEK, István , SIMONIDESZ, Vilmos , GYORI, Péter , NAGY, Lajos , LUGOSI, Márta , SANTANE SINGOLA, Ilona , BESENYI, Gábor , SIMANDI, Lászl(RTM)

IPC分类号： B01J27 , C07B61 , C07C231 , C07C233 , C07C237 , C07D237

CPC分类号： C07C233/00

摘要： The invention relates to a process for the preparation of tetracycline derivatives of formula (I), and acid addition salts thereof, wherein R stands for -CH₃ or = CH₂, by dehalogen ating and hy drating chloromethacycline or acid addition salt thereof of formula (II), or by hydrating methacycline or acid addition salts thereof of formula (III), by a treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises perform ing hydrating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and sele nium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if de sired dehalogenation and hydration in one step.