发明公开
EP0343277A1 A process for the production of 3-hydrocarbyl-3-cephems
失效
Verfahren zur Herstellung von 3-hydrocarbonyl-3-cephemverbindungen。
- 专利标题： A process for the production of 3-hydrocarbyl-3-cephems
- 专利标题（中）： Verfahren zur Herstellung von 3-hydrocarbonyl-3-cephemverbindungen。
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申请号： EP88108505.4申请日： 1988-05-27
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公开(公告)号： EP0343277A1公开(公告)日： 1989-11-29
- 发明人: Baker, Stephen R. , Farina, Vittorio , Sapino, Chester, Jr.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： 345 Park Avenue New York, N.Y. 10154 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： 345 Park Avenue New York, N.Y. 10154 US
- 代理机构： Kinzebach, Werner, Dr.
- 主分类号： C07D501/22
- IPC分类号： C07D501/22 ; C07D501/59 ; C07D501/24
摘要：
There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynyl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(dibenzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.
公开/授权文献
- EP0343277B1 A process for the production of 3-hydrocarbyl-3-cephems 公开/授权日：1994-10-05
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