A process for the production of 3-hydrocarbyl-3-cephems
    3.
    发明公开
    A process for the production of 3-hydrocarbyl-3-cephems 失效
    Verfahren zur Herstellung von 3-hydrocarbonyl-3-cephemverbindungen。

    公开(公告)号:EP0343277A1

    公开(公告)日:1989-11-29

    申请号:EP88108505.4

    申请日:1988-05-27

    摘要: There is disclosed a process for the production of certain 3-hydrocarbyl-3-cephem derivatives wherein the hydrocarbyl group is selected from 1-alkenyl and conjugated and unconjugated 1-polyalkenyl, 1-alkynyl, carbocyclic and heterocyclic aryl, and carbocyclic and heterocyclic arylmethyl and, in the case of the 1-alkenyl and conjugated 1-polyalkenyl derivatives, with substantially complete stereospecificity, by coupling a 3-triflyloxy cephem with a hydrocarbyltributylstannane in the presence of bis(di­benzylideneacetonyl)-palladium, a phosphine, and a metal halide such as, for example, zinc chloride. The 3-unsaturated alkyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.

    摘要翻译: 公开了生产某些3-烃基-3-头孢烯衍生物的方法,其中烃基选自1-烯基和共轭和非共轭1-聚烯基,1-炔基,碳环和杂环芳基,以及碳环和杂环芳基甲基 并且在1-烯基和共轭的1-聚烯基衍生物的情况下具有基本上完全的立体定向性,通过在双(二亚苄基丙酰基) - 钯,膦和金属卤化物的存在下将3-三氟氧基头孢烯与烃基三丁基锡烷偶联 例如氯化锌。 所产生的3-不饱和烷基-3-头孢烯衍生物可用作广谱抗菌剂。