本发明涉及新颖-9H-嘌呤衍生物，特别是新的取代的通式其中Ph代表一个卤素取代的苯基的9-苄基-9H-二嘌呤，R 1是氢或游离的或脂肪族，脂环族，脂环族，脂族和/或 表示和酰基取代的氨基，R 2是卤素，低级烷氧基，低级烷基，或游离或脂肪族，脂环族，脂环族，脂族和/或通过酰基氨基取代，条件是R 2不是卤素其他当Ph为2-氟苯基或条件 2,5-或2,6-二氟苯基且R 1是下式基团-N（R 11）（R 12）（Ia）的其中或者R 11是氢，甲基或乙基，R12是氢，甲基，羟甲基，乙基，正 ，异丙基，环丙基，环戊基或环丙基甲基丙基，或者其中R 11是氢且R 12为甲氧基甲基，是代表，并与进一步的条件是R2各种氯 的，当Ph为3-氯苯基，4-氯苯基或3,4-二氯苯基和R 1是N，N-二甲基氨基，以及式I的新化合物，其中Ph是2-氟苯基或2,6-二氟苯基，R1 N-甲基氨基或N，N-二甲基氨基和R 2是氯，和它们的盐，分别。 这些化合物和它们的盐可以用作药物的活性成分，并且可以在本身已知的方式来制备。

The invention relates to novel 9H-purine derivatives, particularly novel substituted 9-benzyl-9H-purines of the general formula wherein Ph represents a halogen-substituted phenyl, R₁ is hydrogen or a free or aliphatically, cycloaliphatically, cycloaliphatically-aliphatically and / or substituted by acyl amino group and R₂ is halogen, lower alkoxy, lower alkyl or a free or aliphatically, cycloaliphatically, cycloaliphatically-aliphatically and / or is by acyl substituted amino group, with the proviso that R₂ is different from halogen, if Ph is 2-fluorophenyl or 2,5- or 2,6-difluorophenyl and R₁ is a radical of the formula -N (R₁₁) (R₁₂) (Ia) wherein either R₁₁ is hydrogen, methyl or ethyl and R₁₂ is hydrogen, methyl, hydroxymethyl, ethyl, n-propyl, isopropyl, cyclopropyl, cyclopentyl or cyclopropylmethyl, or wherein R₁₁ is hydrogen and R₁₂ methoxymethyl, group, and with the further proviso that R₂ is other than chlorine when Ph is 3-chlorophenyl, 4-chlorophenyl or 3,4-dichlorophenyl and R₁ is N, N-dimethylamino, as well as the novel compounds of formula I in which Ph is 2-fluorophenyl or 2 , 6-difluorophenyl, R₁ is N-methylamino or N, N-dimethylamino and R₂ is chloro, and each have their salts. These compounds and their salts can be used as pharmaceutically active substances and are prepared in a manner known per se.