发明公开
EP0367223A2 Chelants possessing ortho ligating functionality and complexes thereof
失效
Chelatbildner，死亡eine ortho-bindende funktionelle Gruppe besitzen und Komplexe davon。
- 专利标题： Chelants possessing ortho ligating functionality and complexes thereof
- 专利标题（中）： Chelatbildner，死亡eine ortho-bindende funktionelle Gruppe besitzen und Komplexe davon。
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申请号： EP89120190.7申请日： 1989-10-31
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公开(公告)号： EP0367223A2公开(公告)日： 1990-05-09
- 发明人: Wilson, David A. , Garlich, Joseph R. , Frank, Richard K. , McMillan, Kenneth , Simon, Jaime
- 申请人： THE DOW CHEMICAL COMPANY
- 申请人地址： 2030 Dow Center, Abbott Road Midland, Michigan 48640 US
- 专利权人： THE DOW CHEMICAL COMPANY
- 当前专利权人： THE DOW CHEMICAL COMPANY
- 当前专利权人地址： 2030 Dow Center, Abbott Road Midland, Michigan 48640 US
- 代理机构： Prechtel, Jörg, Dipl.-Phys. Dr.
- 优先权： US265158 19881031
- 主分类号： C07C233/54
- IPC分类号： C07C233/54 ; C07C229/42 ; C07C255/25 ; C07C233/43 ; C07C229/16 ; C07C331/28 ; C07F5/00 ; A61K51/00
摘要：
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
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