摘要:
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要:
Compositions and method for therapeutic and/or diagnostic treatment of soft tissue tumors in mammals using certain metals ions or particle-emitting radionuclides complexed with a phenoliccarboxylate ligand is described.
摘要:
Particle emitting radionuclides, e.g. Samarium-153, have been complexed with certain macrocyclic aminophosphonic acids wherein the nitrogen and phosphorus are interconnected by an alkylene group or substituted alkylene group. These complexes have been found useful in compositions and formulations for the therapeutic treatment of calcific tumors and the relief of bone pain in animals.
摘要:
A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.
摘要:
New compounds are represented by Formulas 1 and 2 where Formula 1 is:
wherein each of R 1 , R 2 , R 3 , and R 4 is independently H, hydroxyalkyl, -C(R 6 ) 2 COOH or ammonium, amine, or alkali metal salts thereof; R 5 is an alkylene group having at least one carbonyl group; and each R 6 is independently selected from H, and alkyl groups of from 1 to 4 carbon atoms, straight or branched chain, preferably H, -CH 3 , or -C 2 Hs, more preferably each R 6 is H and Formula 2 is:
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined for Formula 1, preferably at least 3, most preferably 4 of R 1 , R 2 , R 3 , and R 4 are independently -C(R 6 ) 2 COOH or salts thereof; and each R 7 is independently R 5 or an alkylene group. The compounds are advantageously photo- and bio-degradable and are particularly useful as chelants especially in washing compositions and in gas conditioning.