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1.发明公开Chelants possessing ortho ligating functionality and complexes thereof 失效具有正常功能及其复合功能的CHELANTS ORTHO LIGHTING功能及其复合物
公开(公告)号：EP0570022A3
公开(公告)日：1993-11-24
申请号：EP93110124.0
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C233/43 , C07C229/16 , C07C255/25 , C07C331/28 , C07F5/00 , G01N33/534 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
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2.发明授权
公开(公告)号：EP0566166B1
公开(公告)日：1996-09-25
申请号：EP93110123.2
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C233/43 , C07C229/16 , C07C255/25 , C07C331/18 , C07F5/00 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
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3.发明公开Chelants possessing ortho ligating functionality and complexes thereof 失效Chelatbildende Verbindungen，die eine ortho-bindende Gruppe besitzen und ihre Komplexe。
公开(公告)号：EP0570022A2
公开(公告)日：1993-11-18
申请号：EP93110124.0
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C233/43 , C07C229/16 , C07C255/25 , C07C331/28 , C07F5/00 , G01N33/534 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译： 公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。 复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。 此外，某些螯合剂 - 放射性核素复合物可有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。
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4.发明公开Chelants possessing ortho ligating functionality and complexes thereof 失效Chelatbildner，死亡eine ortho-bindende funktionelle Gruppe besitzen und Komplexe davon。
公开(公告)号：EP0367223A2
公开(公告)日：1990-05-09
申请号：EP89120190.7
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C255/25 , C07C233/43 , C07C229/16 , C07C331/28 , C07F5/00 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译： 公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。 复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。 此外，某些螯合剂 - 放射性核素复合物可有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。
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5.发明公开Chelants possessing ortho ligating functionality and complexes thereof 失效Chelatbildende Verbindungen die eine orthobindende Gruppe besitzen und ihre Komplexe。
公开(公告)号：EP0566166A1
公开(公告)日：1993-10-20
申请号：EP93110123.2
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C233/43 , C07C229/16 , C07C255/25 , C07C331/18 , C07F5/00 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
摘要翻译： 公开了一组具有与稀土类金属离子形成络合物的邻位官能团的官能化胺螯合剂。 复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。 此外，某些螯合剂 - 放射性核素复合物可有效地用于可用作钙化肿瘤的治疗和/或诊断剂和/或缓解骨痛的组合物中。
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6.发明公开Chelants possessing ortho ligating functionality and complexes thereof 失效具有正常功能及其复合功能的CHELANTS ORTHO LIGHTING功能及其复合物
公开(公告)号：EP0367223A3
公开(公告)日：1990-09-05
申请号：EP89120190.7
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C255/25 , C07C233/43 , C07C229/16 , C07C331/28 , C07F5/00 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
摘要： A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
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7.发明授权
公开(公告)号：EP0570022B1
公开(公告)日：1996-07-31
申请号：EP93110124.0
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C233/43 , C07C229/16 , C07C255/25 , C07C331/28 , C07F5/00 , G01N33/534 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
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8.发明授权
公开(公告)号：EP0367223B1
公开(公告)日：1995-04-26
申请号：EP89120190.7
申请日：1989-10-31
IPC分类号： C07C233/54 , C07C229/42 , C07C255/25 , C07C233/43 , C07C229/16 , C07C331/28 , C07F5/00 , A61K51/00
CPC分类号： G01N33/534 , A61K51/0478 , A61K2121/00 , A61K2123/00 , C07C229/16 , C07C229/42 , C07C233/43 , C07C233/54 , C07C255/25 , C07C255/30 , C07C331/28 , C07F5/003
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