发明公开
EP0391594A2 Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
失效
的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
- 专利标题： Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
- 专利标题（中）： 的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
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申请号： EP90303300.9申请日： 1990-03-28
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公开(公告)号： EP0391594A2公开(公告)日： 1990-10-10
- 发明人: Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
- 申请人： MERCK & CO. INC.
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Cole, William Gwyn
- 优先权： US331146 19890331; US490723 19900314
- 主分类号： C12N15/52
- IPC分类号： C12N15/52 ; C12N15/76 ; C12P19/62 ; C07H19/01
摘要：
There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis , the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
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