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1.发明公开
公开(公告)号：EP0391594A3
公开(公告)日：1992-01-02
申请号：EP90303300.9
申请日：1990-03-28
申请人： MERCK & CO. INC.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
摘要： There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis , the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
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2.发明授权Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use 失效的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
公开(公告)号：EP0391594B1
公开(公告)日：1995-10-18
申请号：EP90303300.9
申请日：1990-03-28
申请人： Merck & Co., Inc.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
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3.发明公开Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use 失效的链霉菌基因对它们的使用阿维菌素和方法的生物合成克隆。
公开(公告)号：EP0391594A2
公开(公告)日：1990-10-10
申请号：EP90303300.9
申请日：1990-03-28
申请人： MERCK & CO. INC.
发明人： Gewain, Keith M. , Paress, Philip S. , MacNeil, Douglas J. , Ruby, Carolyn L. , Streicher, Stanley S. , MacNeil, Tanya
CPC分类号： C12N15/10 , C12N9/1007 , C12N9/88 , C12N15/52 , C12N15/76 , C12P17/181 , C12P19/623
摘要： There are disclosed plasmids containing DNA isolated from Streptomyces avermitilis , the microorganism which is used to prepare avermectin compounds, identified as pAT1, pVE650 pVE855, pVE859, pVE1446, pVE923, and pVE924 which contain the genetic information for the biosynthesis of the avermectins. Methods for the isolation of such plasmid and for the manipulation of the plasmids to alter the formation of the avermectin compound are also disclosed.
摘要翻译： 有圆盘游离缺失质粒含有来自除虫链霉菌中分离DNA，所述微生物的所有这是用来制备除虫菌素化合物，经鉴定为PAT1，pVE650 pVE855，pVE859，pVE1446，pVE923和pVE924包含用于除虫菌素生物合成的遗传信息。 对于质粒的分离方法并检查质粒的操纵来改变阿维菌素化合物的形成是这样游离缺失盘。
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4.发明授权Process for producing an immunosuppressant agent (demethimmunomycin) using a mutant strain of a microorganism 失效一种用于通过使用微生物的菌株突变体的制备免疫抑制物质（demethimmunomycin）的过程。
公开(公告)号：EP0388152B1
公开(公告)日：1994-10-12
申请号：EP90302669.8
申请日：1990-03-13
申请人： Merck & Co., Inc.
CPC分类号： C12R1/55 , C07H19/01 , C12P17/188
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5.发明公开
公开(公告)号：EP0388152A3
公开(公告)日：1991-05-15
申请号：EP90302669.8
申请日：1990-03-13
申请人： MERCK & CO. INC.
CPC分类号： C12R1/55 , C07H19/01 , C12P17/188
摘要： Described is a new process for producing the immunosuppressant, L-683,742, a C-31 demethylated, derivative of L-683,590 (FK-520), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
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6.发明公开Process for producing an immunosuppressant agent (demethimmunomycin) using a mutant strain of a microorganism 失效一种用于通过使用微生物的菌株突变体的制备免疫抑制物质（demethimmunomycin）的过程。
公开(公告)号：EP0388152A2
公开(公告)日：1990-09-19
申请号：EP90302669.8
申请日：1990-03-13
申请人： MERCK & CO. INC.
CPC分类号： C12R1/55 , C07H19/01 , C12P17/188
摘要： Described is a new process for producing the immunosuppressant, L-683,742, a C-31 demethylated, derivative of L-683,590 (FK-520), produced under fermentation conditions utilizing the new mutant microorganism, Streptomyces hygroscopicus subsp. ascomyceticus (Merck Culture Collection MA 6646) ATCC No. 53855, being a blocked mutant of Streptomyces hygroscopicus subsp. ascomyceticus (MA 6475) ATCC No. 14891. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
摘要翻译： 描述了一种用于生产免疫抑制剂的新工艺，L-683.742，一个C-31脱甲基化，衍生物L-683.590（FK-520）的，发酵条件利用新的微生物突变体吸水链霉菌亚种下产生。 子囊（默克菌种保藏MA 6646）ATCC号 53855，作为吸水链霉菌亚种的封端的突变体。 子囊霉素（MA 6475）ATCC号 该第一万四千八百九十一大环内酯类免疫是预防人类宿主排斥外来器官移植的有用的，例如 骨髓和心脏移植。
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