发明公开
- 专利标题： Pradimicin derivatives
- 专利标题（中）： 普拉定霉素衍。
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申请号： EP90122217.4申请日： 1990-11-20
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公开(公告)号： EP0432527A2公开(公告)日： 1991-06-19
- 发明人: Aburaki, Shimpei , Yamasaki, Tetsuro , Oki, Toshikazu , Iimura, Seiji , Kamachi, Hajime , Kamei, Hideo , Naito, Takayuki
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： 345 Park Avenue New York, N.Y. 10154 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： 345 Park Avenue New York, N.Y. 10154 US
- 代理机构： Kinzebach, Werner, Dr.
- 优先权： US440060 19891122
- 主分类号： C07H15/244
- IPC分类号： C07H15/244 ; A61K31/71 ; C07C235/84
摘要：
The present invention concerns neutral sugar derivatives (Formula I) of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
wherein R¹ is selected from the group consisting of H, methyl, and hydroxymethyl, and when R¹ is methyl or hydroxymethyl, the resulting amino acid residue has the D -configuration; and R² is H or ß- D -xylosyl with the proviso that, when R¹ is methyl, R² is H; or a pharmaceutically acceptable salt thereof.
wherein R¹ is selected from the group consisting of H, methyl, and hydroxymethyl, and when R¹ is methyl or hydroxymethyl, the resulting amino acid residue has the D -configuration; and R² is H or ß- D -xylosyl with the proviso that, when R¹ is methyl, R² is H; or a pharmaceutically acceptable salt thereof.
公开/授权文献
- EP0432527B1 Pradimicin derivatives 公开/授权日：1997-02-05
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