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17 条记录 (耗时 0.015 秒)

    Antitumor antibiotic BU-3285T
    3.
    发明公开
    Antitumor antibiotic BU-3285T 失效
    抗肿瘤抗生素BU-3285T。

    公开(公告)号：EP0408336A2

    公开(公告)日：1991-01-16

    申请号：EP90307579.4

    申请日：1990-07-11

    申请人： Bristol-Myers Squibb Company

    发明人： Ohkuma, Hiroaki ,  Tomita, Koji ,  Konishi, Masataka ,  Kamei, Hideo

    IPC分类号： C07D309/32 ,  C12P17/06 ,  C12N1/20 ,  A61K31/35

    CPC分类号： C07D309/32

    摘要： The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated derivative of BU-3285T which is obtained by treatment of BU-3285T with sulfatase enzyme. BU-3285T desulfate possesses antitumor activity.

    摘要翻译： 本发明涉及抗肿瘤抗生素化合物BU-3285T及其制备方法。 该化合物通过培养一种新的连翘蔷薇菌株获得，并表现出抗肿瘤和抗真菌活性。 它还涉及通过用硫酸酯酶处理BU-3285T获得的BU-3285T的脱硫衍生物。 BU-3285T硫酸盐具有抗肿瘤活性。

    Pradimicin derivatives
    5.
    发明公开
    Pradimicin derivatives 失效
    PRADIMICIN衍生物

    公开(公告)号：EP0432527A3

    公开(公告)日：1991-12-04

    申请号：EP90122217.4

    申请日：1990-11-20

    申请人： Bristol-Myers Squibb Company

    发明人： Aburaki, Shimpei ,  Yamasaki, Tetsuro ,  Oki, Toshikazu ,  Iimura, Seiji ,  Kamachi, Hajime ,  Kamei, Hideo ,  Naito, Takayuki

    IPC分类号： C07H15/244 ,  A61K31/71 ,  C07C235/84

    CPC分类号： C07H15/244 ,  C07C235/84 ,  C07C2603/90

    摘要： The present invention concerns neutral sugar derivatives (Formula I) of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
    wherein R¹ is selected from the group consisting of H, methyl, and hydroxymethyl, and when R¹ is methyl or hydroxymethyl, the resulting amino acid residue has the D -configuration; and R² is H or ß- D -xylosyl with the proviso that, when R¹ is methyl, R² is H; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及普拉德霉素的中性糖衍生物（式I），它们作为抗真菌剂的用途，其制备方法及其合成中间体。 其中R 1选自H，甲基和羟甲基，当R 1为甲基或羟甲基时，所得氨基酸残基具有D-构型; 且R 2为H或β-D-木糖基，条件是当R 1为甲基时，R 2为H; 或其药学上可接受的盐。

    Acylated derivatives of etoposide
    6.
    发明公开
    Acylated derivatives of etoposide 失效
    ETOPOSIDE的衍生物衍生物

    公开(公告)号：EP0401800A3

    公开(公告)日：1991-04-10

    申请号：EP90110729.2

    申请日：1990-06-06

    申请人： Bristol-Myers Squibb Company

    发明人： Ohnuma, Takeshi ,  Obata, Rika ,  Kamei, Hideo ,  Naito, Takayuki

    IPC分类号： C07H17/04 ,  A61K31/70

    CPC分类号： C07H17/04

    摘要： The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia
    wherein R² is H and R¹ is selected from the group consisting of (C₁₋₁₀)alkyl, (C₂₋₁₀)alkenyl, (C₅₋₆)cycloalkyl, 2-furyl, 2-thienyl, (C₆₋₁₀)aryl, and (C₇₋₁₄)aralkyl; or R¹ and R² are each (C₁₋₁₀)alkyl; or R¹, R² and the carbon to which they are attached together represent (C₅₋₆)cycloalkyl; one of R³ and R⁴ is H and the other is selected from the group consisting of (C₁₋₅)alkanoyl and benzoyl; or R³ and R⁴ are the same or different and are selected from the group consisting of (C₁₋₅)alkanoyl and benzoyl; R⁵ is H or a phosphate group.

    Fluoro-substituted epipodophyllotoxin glucosides
    8.
    发明公开
    Fluoro-substituted epipodophyllotoxin glucosides 失效
    氟代显性表鬼臼毒素。

    公开(公告)号：EP0358197A2

    公开(公告)日：1990-03-14

    申请号：EP89116448.5

    申请日：1989-09-06

    申请人： Bristol-Myers Squibb Company

    发明人： Ohnuma, Takeshi ,  Yamasaki, Tetsuro ,  Kamei, Hideo ,  Naito, Takayuki

    IPC分类号： C07H17/04 ,  A61K31/70

    CPC分类号： C07H17/04 ,  Y02P20/55

    摘要： The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.

    摘要翻译： 本发明提供抗肿瘤氟取代的4'-去甲表鬼臼毒素葡糖苷（I）。 其中R 2是H，R 1选自（C 1-10）烷基; （C 2-10）链烯基; （C 5-6）环烷基; 2-呋喃基; 2-噻吩基; （C 6-10）芳基; （C7-14）芳烷基; 和（C 8-14）芳烯基，其中每个芳环可以是未取代的或被一个或多个选自卤素，（C 1-8）烷基，（C 1-8）烷氧基，羟基，硝基和氨基的基团取代; 或R 1和R 2各自为（C 1-8）烷基; 或R 1和R 2和它们所连接的碳连接形成（C5-6）环烷基; R 3或R 4之一是OH，另一个是F; R 5为H或苯酚保护基; 而“IMAGE”代表α-或β-糖苷键。

    Pradimicin derivatives
    10.
    发明公开
    Pradimicin derivatives 失效
    普拉定霉素衍。

    公开(公告)号：EP0432527A2

    公开(公告)日：1991-06-19

    申请号：EP90122217.4

    申请日：1990-11-20

    申请人： Bristol-Myers Squibb Company

    发明人： Aburaki, Shimpei ,  Yamasaki, Tetsuro ,  Oki, Toshikazu ,  Iimura, Seiji ,  Kamachi, Hajime ,  Kamei, Hideo ,  Naito, Takayuki

    IPC分类号： C07H15/244 ,  A61K31/71 ,  C07C235/84

    CPC分类号： C07H15/244 ,  C07C235/84 ,  C07C2603/90

    摘要： The present invention concerns neutral sugar derivatives (Formula I) of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
    wherein R¹ is selected from the group consisting of H, methyl, and hydroxymethyl, and when R¹ is methyl or hydroxymethyl, the resulting amino acid residue has the D -configuration; and R² is H or ß- D -xylosyl with the proviso that, when R¹ is methyl, R² is H; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及普拉德霉素的中性糖衍生物（式I），它们作为抗真菌剂的用途，其制备方法及其合成中间体。 其中R 1选自H，甲基和羟甲基，当R 1为甲基或羟甲基时，所得氨基酸残基具有D-构型; 且R 2为H或β-D-木糖基，条件是当R 1为甲基时，R 2为H; 或其药学上可接受的盐。