发明公开
EP0450327A1 Biosynthesis of rebeccamycin analogs by tryptophan analogs feeding
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Rebeccamycinanaloga - Biosynthese durchZuführungvon Tryptophananalogen。
- 专利标题: Biosynthesis of rebeccamycin analogs by tryptophan analogs feeding
- 专利标题(中): Rebeccamycinanaloga - Biosynthese durchZuführungvon Tryptophananalogen。
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申请号: EP91103316.5申请日: 1991-03-05
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公开(公告)号: EP0450327A1公开(公告)日: 1991-10-09
- 发明人: Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jacqueline , Forenza, Salvatore , Matson, James A.
- 申请人: Bristol-Myers Squibb Company
- 申请人地址: 345 Park Avenue New York, N.Y. 10154 US
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: 345 Park Avenue New York, N.Y. 10154 US
- 代理机构: Kinzebach, Werner, Dr.
- 优先权: US489430 19900306; US648751 19910205
- 主分类号: C07H19/04
- IPC分类号: C07H19/04 ; C12P19/28 ; A61K31/71
摘要:
Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
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