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公开(公告)号：EP0329109B1
公开(公告)日：1992-11-19
申请号：EP89102599.1
申请日：1989-02-15
发明人： Lam, Kin Sing , Mattei, Jacqueline , Leet, John Emerick , Matson, James Andrew , Tomita, Koji , Kaplan, Murray A.
摘要： A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
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公开(公告)号：EP0450327B1
公开(公告)日：1996-06-05
申请号：EP91103316.5
申请日：1991-03-05
发明人： Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jacqueline , Forenza, Salvatore , Matson, James A.
CPC分类号： C07H19/044 , C12P19/28
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3.发明公开Biosynthesis of rebeccamycin analogs by tryptophan analogs feeding 失效Rebeccamycinanaloga - Biosynthese durchZuführungvon Tryptophananalogen。
公开(公告)号：EP0450327A1
公开(公告)日：1991-10-09
申请号：EP91103316.5
申请日：1991-03-05
发明人： Lam, Kin Sing , Schroeder, Daniel R. , Mattei, Jacqueline , Forenza, Salvatore , Matson, James A.
CPC分类号： C07H19/044 , C12P19/28
摘要： Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.
摘要翻译： 在发酵过程中，某些色氨酸类似物在重新克雷霉素生产菌株的发酵过程中向培养基中加入，导致产生具有有利抗肿瘤性质的新的雷贝卡霉素类似物。
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公开(公告)号：EP0388962A2
公开(公告)日：1990-09-26
申请号：EP90105446.0
申请日：1990-03-22
IPC分类号： C07H19/044 , A61K31/70
CPC分类号： C07H19/04 , Y10S435/898
摘要： A new antitumor antibiotic designated BMY-41950 of formula (I) is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
摘要翻译： 命名为式（I）的BMY-41950的新的抗肿瘤抗生素通过Stautomyces staurosporeus ATCC 55006或吸水链霉菌ATCC 53730的发酵产生.BMY-41950抗生素表现出抗微生物和抗肿瘤活性。 （CHEM）（
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公开(公告)号：EP0388962B1
公开(公告)日：1994-09-14
申请号：EP90105446.0
申请日：1990-03-22
IPC分类号： C07H19/044 , A61K31/70
CPC分类号： C07H19/04 , Y10S435/898
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公开(公告)号：EP0388962A3
公开(公告)日：1991-01-16
申请号：EP90105446.0
申请日：1990-03-22
IPC分类号： C07H19/044 , A61K31/70
CPC分类号： C07H19/04 , Y10S435/898
摘要： A new antitumor antibiotic designated BMY-41950 of formula (I) is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.
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公开(公告)号：EP0329109A1
公开(公告)日：1989-08-23
申请号：EP89102599.1
申请日：1989-02-15
发明人： Lam, Kin Sing , Mattei, Jacqueline , Leet, John Emerick , Matson, James Andrew , Tomita, Koji , Kaplan, Murray A.
摘要： A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
摘要翻译： 名为BMY-40800的新型抗肿瘤抗生素通过发酵吸水链霉菌ATCC 53653产生。新化合物抑制实验动物的肿瘤生长。
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