发明公开
EP0451763A3 Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives
失效
具有AMPHIPHATIC性质的肽衍生物，其中间体和脂质体以及包含上述衍生物的膜
- 专利标题： Peptide derivatives with amphiphatic properties, intermediates thereof and liposomes and films comprising said derivatives
- 专利标题（中）： 具有AMPHIPHATIC性质的肽衍生物，其中间体和脂质体以及包含上述衍生物的膜
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申请号： EP91105549.9申请日： 1991-04-08
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公开(公告)号： EP0451763A3公开(公告)日： 1991-12-04
- 发明人: Kitaguchi, Hiroshi , Nemori, Ryoichi
- 申请人： FUJI PHOTO FILM CO., LTD.
- 申请人地址： 210 Nakanuma Minami Ashigara-shi Kanagawa JP
- 专利权人： FUJI PHOTO FILM CO., LTD.
- 当前专利权人： FUJI PHOTO FILM CO., LTD.
- 当前专利权人地址： 210 Nakanuma Minami Ashigara-shi Kanagawa JP
- 代理机构： Grünecker, Kinkeldey, Stockmair & SchwanhÀ¤usser Anwaltssozietät
- 优先权： JP93482/90 19900409; JP203218/90 19900731
- 主分类号： C07K5/00
- IPC分类号： C07K5/00 ; C07K7/00 ; A61K9/127
摘要：
A peptide derivative amphiphatic compound or N-terminal salt thereof represented by formula (I):
wherein R¹ and R² each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents -O-or -NH-; R 3n and R 3(n+1) each represents an α-amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component;
an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.
wherein R¹ and R² each represents a straight-chain or branched alkyl or acyl group having 8 to 24 carbon atoms optionally having a substituent or an unsaturated group; X represents -O-or -NH-; R 3n and R 3(n+1) each represents an α-amino acid side chain; n is an integer of from 0 to 5; the compound may be a racemic compound or an optically active compound when the compound has an asymmetric carbon atom; and the N-terminal salt of the compound optionally forms with an acid component;
an intermediate thereof, a liposome comprising said peptide derivative amphiphatic compound and a film consisting of a monolayer or multilayers comprising the peptide derivative amphiphatic compound are disclosed.
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