发明公开
EP0459779A1 Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) GP120 and methods of use
失效
免疫试剂与人类免疫缺陷病毒I（HIV-I）GP120和它们的使用方法的一个保守的表位反应性的。
- 专利标题： Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) GP120 and methods of use
- 专利标题（中）： 免疫试剂与人类免疫缺陷病毒I（HIV-I）GP120和它们的使用方法的一个保守的表位反应性的。
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申请号： EP91304840.1申请日： 1991-05-29
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公开(公告)号： EP0459779A1公开(公告)日： 1991-12-04
- 发明人: Ho, David Da-i , Robinson, James Edmun
- 申请人： Cedars-Sinai Medical Center , LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE
- 申请人地址： 8700 Beverly Boulevard Los Angeles, California 90048-0750 US
- 专利权人： Cedars-Sinai Medical Center,LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE
- 当前专利权人： Cedars-Sinai Medical Center,LOUISIANA STATE UNIVERSITY AGRICULTURAL AND MECHANICAL COLLEGE
- 当前专利权人地址： 8700 Beverly Boulevard Los Angeles, California 90048-0750 US
- 代理机构： Goldin, Douglas Michael
- 优先权： US530850 19900529; US701129 19910516
- 主分类号： C12P21/08
- IPC分类号： C12P21/08 ; C12N5/10 ; A61K39/42 ; G01N33/569 ; G01N33/577
摘要：
The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.
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