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1.发明公开Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) GP120 and methods of use 失效免疫试剂与人类免疫缺陷病毒I（HIV-I）GP120和它们的使用方法的一个保守的表位反应性的。
公开(公告)号：EP0459779A1
公开(公告)日：1991-12-04
申请号：EP91304840.1
申请日：1991-05-29
IPC分类号： C12P21/08 , C12N5/10 , A61K39/42 , G01N33/569 , G01N33/577
CPC分类号： C07K14/70514 , A61K38/00 , C07K16/1063 , C07K16/462 , C07K2317/24 , C07K2317/732
摘要： The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.
摘要翻译： 本发明的特征哪通过结合至HIV-1的gp120的新的保守表位的中和人免疫缺陷病毒1型（HIV-1）免疫试剂。 这些免疫试剂表现出在HIV附着的广泛中和作用对宿主细胞，并且在检测因此，预防，改善和治疗HIV疾病，主要是AIDS（获得性免疫缺陷综合征）和ARC（AIDS相关复合体）是有用的。 更具体地，本发明涉及新的人单克隆抗体与HIV-1的gp120的保守构象依赖性决定簇选择性反应，其衍生物，细胞系确实产生合成抗体，和使用用于检测的单克隆抗体和它们的衍生物， 预防，改善和治疗艾滋病相关的疾病。
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2.发明授权Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) GP120 and methods of use 失效免疫试剂与人类免疫缺陷病毒I（HIV-I）GP120和它们的使用方法的一个保守的表位反应性的。
公开(公告)号：EP0459779B1
公开(公告)日：1994-12-07
申请号：EP91304840.1
申请日：1991-05-29
IPC分类号： C12P21/08 , C12N5/10 , A61K39/42 , G01N33/569 , G01N33/577
CPC分类号： C07K14/70514 , A61K38/00 , C07K16/1063 , C07K16/462 , C07K2317/24 , C07K2317/732
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