发明授权
- 专利标题： NOVEL NEUROTHROPHIC FACTOR
- 专利标题（中）： 新的神经营养因子
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申请号： EP91918727.8申请日： 1991-09-24
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公开(公告)号： EP0550665B1公开(公告)日： 1996-07-31
- 发明人: ROSENTHAL, Arnon
- 申请人： GENENTECH, INC.
- 申请人地址： 460 Point San Bruno Boulevard South San Francisco California 94080 US
- 专利权人： GENENTECH, INC.
- 当前专利权人： GENENTECH, INC.
- 当前专利权人地址： 460 Point San Bruno Boulevard South San Francisco California 94080 US
- 代理机构： Stuart, Ian Alexander
- 优先权： US587707 19900925; US648482 19910131
- 国际公布： WO9205254 19920402
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12Q1/68 ; C12P21/08
摘要：
A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4β, NT-4η, and NT-4Δ. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
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