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公开(公告)号：EP1064376A2
公开(公告)日：2001-01-03
申请号：EP99913993.4
申请日：1999-03-19
申请人： Genentech, Inc.
IPC分类号： C12N15/12 , C07K14/71 , C12N15/85 , C12N15/70 , C12N15/81 , C12N1/19 , C12N5/10 , C12N1/21 , C07K19/00 , C07K16/28 , G01N33/68 , C12Q1/42 , A61K39/395
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTS'S), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRx3, a x-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an x-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced x-subunit receptor homo-dimerization or homo-oligomerization.
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公开(公告)号：EP1056868A1
公开(公告)日：2000-12-06
申请号：EP99909610.0
申请日：1999-02-25
申请人： Genentech, Inc.
CPC分类号： C12N9/1205 , C07K2319/00
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human and vertebrate fused.
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公开(公告)号：EP1064376B1
公开(公告)日：2006-03-15
申请号：EP99913993.4
申请日：1999-03-19
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C07K14/71 , C12N15/85 , C12N15/70 , C12N15/81 , C12N1/19 , C12N5/10 , C12N1/21 , C07K19/00 , C07K16/28 , G01N33/68 , C12Q1/42 , A61K39/395
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
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公开(公告)号：EP1007666B1
公开(公告)日：2005-12-14
申请号：EP98906558.6
申请日：1998-02-17
申请人： GENENTECH, INC.
IPC分类号： C12N15/12 , C07K14/71 , C07K19/00 , C07K16/46 , G01N33/68 , C07K1/22 , C07K16/28 , A61K38/17 , A61K39/395 , C12N15/85 , C12N5/10 , A01K67/027
CPC分类号： C07K14/71 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00
摘要： NTNR alpha , NTNR alpha extracellular domain (ECD), NTNR alpha variants, chimeric NTNR alpha (e.g., NTNR alpha immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNR alpha -ligands, for example NTN, by providing NTNR alpha to the cell.
摘要翻译： NTNRα，NTNRα胞外结构域（ECD），NTNRα变体，嵌合NTNRα（例如NTNRα免疫粘附）和与其结合的抗体（包括激动剂和中和抗体）。 描述了这些分子的各种用途，包括通过向细胞提供NTNRα而响应于NTNRα-配体，例如NTN，调节细胞活性和存活的方法。
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公开(公告)号：EP1354029A2
公开(公告)日：2003-10-22
申请号：EP01987257.1
申请日：2001-11-01
申请人： Genentech, Inc.
发明人： GUO, Su , ROSENTHAL, Arnon
CPC分类号： C07K14/461
摘要： The present invention relates to neucleotide and amino acid sequences having homology to the zebrafish transcription elongation factor foggy, and to neuronal formation, to a method of directing the differentiation of neuroprogenitor cells into dopaminergic or serotonergic neurons and to a method of treating disorders characterized by abnormalites in and the activity of dopaminergic and serotonergic neurons.
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公开(公告)号：EP0888385B1
公开(公告)日：2003-08-20
申请号：EP97915160.2
申请日：1997-03-13
申请人： Genentech, Inc.
IPC分类号： C07K14/71
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
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公开(公告)号：EP0550665A1
公开(公告)日：1993-07-14
申请号：EP91918727.0
申请日：1991-09-24
申请人： GENENTECH, INC.
发明人： ROSENTHAL, Arnon
IPC分类号： A61K38 , A61K39 , A61K48 , A61P25 , C07K1 , C07K7 , C07K14 , C07K16 , C12N15 , C12P21 , C12Q1
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475
摘要： Un nouveau polypeptide, appelé facteur neurotrophique-4 (NT-4), a été identifié par amplification en utilisant la réaction en chaîne de la polymérase de l'ADN génomique humain. On décrit un acide nucléique codant le NT-4 qui est utile pour des diagnostics et pour la préparation de recombinaison du NT-4. On décrit en outre des acides nucléiques codant des variations de séquence aminoacide du NT-4 se produisant naturellement, qui sont appelées NT-4beta, NT-4gamma et NT-4DELTA. Les facteurs neurotrophiques de la présente invention sont utiles pour le traitement de cellules nerveuses et pour des études diagnostiques.
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公开(公告)号：EP1056868B1
公开(公告)日：2011-08-24
申请号：EP99909610.0
申请日：1999-02-25
申请人： Genentech, Inc.
CPC分类号： C12N9/1205 , C07K2319/00
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists to human and vertebrate fused.
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公开(公告)号：EP0888385A2
公开(公告)日：1999-01-07
申请号：EP97915160.0
申请日：1997-03-13
申请人： Genentech, Inc.
IPC分类号： C12N15 , A01K67 , A61K31 , A61K38 , A61K39 , A61P13 , C07K14 , C07K16 , C07K19 , C12N5 , C12P21 , G01N33
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
摘要： GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRæ (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.
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公开(公告)号：EP0550665B1
公开(公告)日：1996-07-31
申请号：EP91918727.8
申请日：1991-09-24
申请人： GENENTECH, INC.
发明人： ROSENTHAL, Arnon
CPC分类号： C07K16/22 , A61K38/00 , C07K14/475
摘要： A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is nucleic acid encoding NT-4 useful in diagnostics and in the recombinant preparation of NT-4. Also provided herein are nucleic acids encoding naturally occurring amino acid sequence variants of NT-4, designated NT-4β, NT-4η, and NT-4Δ. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
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