发明公开
- 专利标题： REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS
- 专利标题（中）： 通过受体CHIMERAS重组细胞免疫
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申请号： EP92907958申请日： 1992-03-06
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公开(公告)号： EP0574512A4公开(公告)日： 1997-03-12
- 发明人: SEED BRIAN , ROMEO CHARLES , KOLANUS WALDEMAR
- 申请人： GEN HOSPITAL CORP
- 专利权人： GEN HOSPITAL CORP
- 当前专利权人： GEN HOSPITAL CORP
- 优先权： US66596191 1991-03-07
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61K35/14 ; A61K38/00 ; A61K39/395 ; A61K39/42 ; A61K48/00 ; A61P35/00 ; A61P37/00 ; C07K14/00 ; C07K14/705 ; C07K14/725 ; C07K14/73 ; C07K14/735 ; C07K16/00 ; C07K19/00 ; C12N5/00 ; C12N5/10 ; C12N9/12 ; C12N15/00 ; C12N15/09 ; C12N15/62 ; C12N15/63 ; C12P21/08 ; A61K37/12 ; C07K3/00 ; C07K13/00 ; C07K15/00 ; C07K17/00
摘要：
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
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