发明公开
- 专利标题： Linear peptides
- 专利标题（中）： Lineare肽。
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申请号： EP93109532.7申请日： 1993-06-15
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公开(公告)号： EP0576898A2公开(公告)日： 1994-01-05
- 发明人: Jonczyk, Alfred, Dr. , Felding-Habermann, Brundhilde, Dr. , Melzer, Guido, Dr. , Diefenbach, Beate , Cheresh, David A., Dr.
- 申请人： MERCK PATENT GmbH
- 申请人地址： Postfach, Frankfurter Strasse 250 D-64271 Darmstadt DE
- 专利权人： MERCK PATENT GmbH
- 当前专利权人： MERCK PATENT GmbH
- 当前专利权人地址： Postfach, Frankfurter Strasse 250 D-64271 Darmstadt DE
- 优先权： US900385 19920618
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C07K7/08 ; A61K37/02
摘要：
The invention relates to novel linear peptides of Formulae Ia - In
(Ia) H-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ib) H-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ic) H-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Id) H-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ie) H-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(If) H-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ig) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ih) H-Gly-Asp-Gly-Arg-His-Asp-Leu-OH;
(Ii) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-OH;
(Ij) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-OH;
(Ik) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-OH;
(Il) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
(Im) Ac-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
(In) Ac-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
wherein Ac stands for acetyl, and salts thereof.
These substances inhibit, inter alia , cell adhesion.
(Ia) H-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ib) H-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ic) H-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Id) H-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ie) H-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(If) H-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ig) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-Tyr-OH;
(Ih) H-Gly-Asp-Gly-Arg-His-Asp-Leu-OH;
(Ii) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-OH;
(Ij) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-OH;
(Ik) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-OH;
(Il) H-Gly-Asp-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
(Im) Ac-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
(In) Ac-Gly-Arg-His-Asp-Leu-Leu-Val-Gly-Ala-Pro-Leu-OH;
wherein Ac stands for acetyl, and salts thereof.
These substances inhibit, inter alia , cell adhesion.
公开/授权文献
- EP0576898A3 Linear peptides 公开/授权日：1994-04-13
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