发明公开
- 专利标题： Xanthine derivatives
- 专利标题（中）： 黄嘌呤衍生物。
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申请号： EP93120842.5申请日： 1993-12-23
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公开(公告)号： EP0607607A1公开(公告)日： 1994-07-27
- 发明人: Suzuki, Fumio , Shimada, Junichi , Koike, Nobuaki , Kase, Hiroshi , Nakamura, Joji , Shiozaki, Shizuo , Nonaka, Hiromi
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： 6-1, Ohtemachi 1-chome Chiyoda-ku, Tokyo-to JP
- 代理机构： VOSSIUS & PARTNER
- 优先权： JP344116/92 19921224
- 主分类号： C07D473/06
- IPC分类号： C07D473/06 ; A61K31/52
摘要：
Disclosed are xanthine derivatives represented by the following Formula (I):
in which R¹, R², and R³ independently represent hydrogen or lower alkyl;
Q¹, Q², and Q³ independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;
and X represents -COR⁴ (in which R⁴ represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or -SO₂R⁵ {in which R⁵ represents hydroxy, lower alkoxy, trifluoromethyl,
in which R⁶ and R⁷ independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or
(in which m represents an integer of 1 to 3; and R⁸ and R⁹ independently represent hydrogen or lower alkyl), or
(in which Y represents a single bond, oxygen, or N-R¹⁰ in which R¹⁰ represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3 )}, and pharmaceutically acceptable salts thereof.
in which R¹, R², and R³ independently represent hydrogen or lower alkyl;
Q¹, Q², and Q³ independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;
and X represents -COR⁴ (in which R⁴ represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or -SO₂R⁵ {in which R⁵ represents hydroxy, lower alkoxy, trifluoromethyl,
in which R⁶ and R⁷ independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or
(in which m represents an integer of 1 to 3; and R⁸ and R⁹ independently represent hydrogen or lower alkyl), or
(in which Y represents a single bond, oxygen, or N-R¹⁰ in which R¹⁰ represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3 )}, and pharmaceutically acceptable salts thereof.
公开/授权文献
- EP0607607B1 Xanthine derivatives 公开/授权日：1996-09-18
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