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10 条记录 (耗时 0.015 秒)

    Xanthine derivatives
    3.
    发明公开
    Xanthine derivatives 失效
    黄嘌呤衍生物

    公开(公告)号：EP0556778A3

    公开(公告)日：1993-11-24

    申请号：EP93102412.9

    申请日：1993-02-16

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Ishii, Akio ,  Shiozaki, Shizuo

    IPC分类号： C07D473/04 ,  A61K31/52

    CPC分类号： C07D473/04

    摘要： A xanthine derivative of the formula (I):

    wherein R 1 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl;
    R 2 represents -(CH2)m-X, wherein m is 2 or 3, and X is

    wherein a is NH, O or S, b and d are the same or different and are CH or N, and R 3 is lower alkyl, substituted or unsubstituted alicyclic alkyl, or substituted or unsubstituted phenyl, or wherein e, g and h are the same or different and are CH or N, and R 3 is the same as defined above; Q represents substituted or unsubstituted alicyclic alkyl,
    wherein R 4 and R 5 are the same or different and are substituted or unsubstituted alicyclic alkyl,
    wherein Y is single bond or alkylene; and n is 0 or 1,
    wherein K-M is -CH 2 -CH 2 - or -CH = CH-, and Y is the same as defined above, or
    wherein Y is the same as defined above; or a pharmacologically acceptable salt thereof is disclosed. This derivative has anti-dementia activity.

    摘要翻译： 式（I）的黄嘌呤衍生物：其中R1代表取代或未取代的低级烷基，低级链烯基，低级炔基，取代或未取代的脂环族烷基，取代或未取代的苯基或取代或未取代的苄基; R2表示 - （CH2）mX，其中m为2或3，X为其中a为NH，O或S，b和d相同或不同，为CH或N，R3为低级烷基，取代或未取代的 脂环族的烷基或取代或未取代的苯基，或者e，g和h相同或不同，为CH或N，R3与上述定义相同; Q表示取代或未取代的脂环族烷基，其中R4和R5相同或不同并且是取代或未取代的脂环族烷基，其中Y是单键或亚烷基; 并且n是0或1，其中K-M是-CH 2 -CH 2 - 或-CH = CH-，并且Y与以上定义的相同，或者其中Y与以上定义的相同; 或其药理学上可接受的盐。 该衍生物具有抗痴呆活性。

    Xanthine derivatives
    7.
    发明公开
    Xanthine derivatives 失效
    黄嘌呤衍生物。

    公开(公告)号：EP0607607A1

    公开(公告)日：1994-07-27

    申请号：EP93120842.5

    申请日：1993-12-23

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Koike, Nobuaki ,  Kase, Hiroshi ,  Nakamura, Joji ,  Shiozaki, Shizuo ,  Nonaka, Hiromi

    IPC分类号： C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/06

    摘要： Disclosed are xanthine derivatives represented by the following Formula (I):

    in which R¹, R², and R³ independently represent hydrogen or lower alkyl;
    Q¹, Q², and Q³ independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;
    and X represents -COR⁴ (in which R⁴ represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or -SO₂R⁵ {in which R⁵ represents hydroxy, lower alkoxy, trifluoromethyl,

    in which R⁶ and R⁷ independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or

    (in which m represents an integer of 1 to 3; and R⁸ and R⁹ independently represent hydrogen or lower alkyl), or

    (in which Y represents a single bond, oxygen, or N-R¹⁰ in which R¹⁰ represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3 )}, and pharmaceutically acceptable salts thereof.

    摘要翻译： 公开了由下式（I）表示的黄嘌呤衍生物：其中R 1，R 2和R 3独立地表示氢或低级烷基的 Q 1，Q 2和Q 3独立地表示氢，低级烷基，低级烷氧基或卤素; 并且X表示-COR 4（其中R 4表示氢，羟基，低级烷基或低级烷氧基）或-SO 2 R 5（其中R 5表示羟基，低级烷氧基，三氟甲基，CHEM 其中R 6和R 7独立地表示氢，羟基取代或未取代的低级烷基，芳基或（其中m表示1至3的整数;并且R 8和R 8' 或其中Y表示单键，氧或NR 1，其中R 1表示氢或低级烷基;和n1 和n2独立地表示1〜3的整数）}及其药学上可接受的盐。

    Xanthine derivatives
    8.
    发明公开
    Xanthine derivatives 失效
    Xanthinderivate。

    公开(公告)号：EP0556778A2

    公开(公告)日：1993-08-25

    申请号：EP93102412.9

    申请日：1993-02-16

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Ishii, Akio ,  Shiozaki, Shizuo

    IPC分类号： C07D473/04 ,  A61K31/52

    CPC分类号： C07D473/04

    摘要： A xanthine derivative of the formula (I):

    wherein R 1 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl;

    R 2 represents -(CH2)m-X, wherein m is 2 or 3, and X is

    wherein a is NH, O or S, b and d are the same or different and are CH or N, and R 3 is lower alkyl, substituted or unsubstituted alicyclic alkyl, or substituted or unsubstituted phenyl, or

    wherein e, g and h are the same or different and are CH or N, and R 3 is the same as defined above; Q represents substituted or unsubstituted alicyclic alkyl,

    wherein R 4 and R 5 are the same or different and are substituted or unsubstituted alicyclic alkyl,

    wherein Y is single bond or alkylene; and n is 0 or 1,

    wherein K-M is -CH 2 -CH 2 - or -CH = CH-, and Y is the same as defined above, or

    wherein Y is the same as defined above;
    or a pharmacologically acceptable salt thereof is disclosed. This derivative has anti-dementia activity.

    摘要翻译： 式（I）的黄嘌呤衍生物：其中R 1表示取代或未取代的低级烷基，低级烯基，低级炔基，取代或未取代的脂环族烷基，取代或未取代的苯基或取代或未取代的苄基; R 2表示 - （CH 2）m X，其中m为2或3，X为其中a为NH，O或S，b和d相同或不同，为CH或N， 3'是低级烷基，取代或未取代的脂环族烷基或取代或未取代的苯基或，其中e，g和h相同或不同，为CH或N，R 3与上述定义相同 ; Q表示取代或未取代的脂环族烷基，其中R 4和R 5相同或不同，为取代或未取代的脂环族烷基，其中Y为单键或亚烷基; 和n为0或1，其中K-M是-CH 2 -CH 2 - 或-CH = CH-，Y与上述定义相同，或其中Y与上述定义相同; 或其药理学上可接受的盐。 该衍生物具有抗痴呆活性。

    S-triazolo[3,4-i]purine derivatives
    10.
    发明公开
    S-triazolo[3,4-i]purine derivatives 失效
    5三唑并（3,4-i）的purinderivate。

    公开(公告)号：EP0417790A2

    公开(公告)日：1991-03-20

    申请号：EP90117662.8

    申请日：1990-09-13

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Ohmori, Kenji ,  Manabe, Haruhiko ,  Kubo, Kazuhiro ,  Karasawa, Akira ,  Ohno, Tetsuji ,  Shiozaki, Shizuo ,  Ishii, Akio ,  Shuto, Katsuichi

    IPC分类号： C07D487/14 ,  A61K31/52 ,  A61K31/505

    CPC分类号： C07D471/14

    摘要： There are disclosed s-triazolo[3,4-i]purine derivatives represented by formula:

    wherein Y-Z represents

    where R⁴ represents hydrogen, alkyl, substituted or unsubstituted aromatic heterocyclic group or substituted or unsubstituted aryl; and X² represents oxygen, sulfur or NH; each of R¹ and R² independently represents hydrogen, alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; R³ represents alkyl, cycloalkyl, aralkyl or substituted or unsubstituted aryl; X¹ represents oxygen or sulfur; and
    represents a single bond or a double bond or pharmaceutically acceptable salts thereof.

    摘要翻译： 公开了由式：表示的三唑并[3,4-i]嘌呤衍生物，其中Y-Z表示，其中R 4表示氢，烷基，取代或未取代的芳族杂环基或取代或未取代的芳基; X 2表示氧，硫或NH; R 1和R 2各自独立地表示氢，烷基，环烷基，芳烷基或取代或未取代的芳基; R 3表示烷基，环烷基，芳烷基或取代或未取代的芳基; X 1表示氧或硫; 和表示单键或双键或其药学上可接受的盐。