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11 条记录 (耗时 0.014 秒)

    Xanthine derivatives
    1.
    发明公开
    Xanthine derivatives 失效
    叶黄素衍。

    公开(公告)号：EP0619316A1

    公开(公告)日：1994-10-12

    申请号：EP94105380.3

    申请日：1994-04-07

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Shimada, Junichi ,  Kuwabara, Takashi ,  Yasuzawa, Tohru ,  Magara, Hiroshi ,  Nonaka, Hiromi ,  Kusaka, Hideaki ,  Suzuki, Fumio

    IPC分类号： C07D473/04 ,  A61K31/52

    CPC分类号： C07D473/04 ,  Y10S514/869

    摘要： There is provided a novel xanthine Compound(I)

    wherein R¹ and R² are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is

    wherein R³ and R⁴ are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R³ and R⁴ are hydrogen, at least one of R¹ and R² is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof.
    The xanthine compound has adenosine A₁ receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.

    摘要翻译： 提供了一种新颖的黄嘌呤化合物（I）其中R 1和R 2相同或不同，各自表示羟基取代的，取代或未取代的低级烷基，Y是单键或亚烷基 且Q为，其中R 3和R 4相同或不同，各自表示氢或羟基，n为0或1; 条件是当R 3和R 4都是氢时，R 1和R 2中的至少一个是羟基取代的或氧代取代的低级烷基; 或其药学上可接受的盐。 黄嘌呤化合物具有腺苷A1受体拮抗活性，因此具有利尿作用，肾保护作用，支气管扩张作用，脑功能改善作用和抗痴呆作用。

    Xanthine derivatives
    4.
    发明公开
    Xanthine derivatives 失效
    黄嘌呤衍生物。

    公开(公告)号：EP0607607A1

    公开(公告)日：1994-07-27

    申请号：EP93120842.5

    申请日：1993-12-23

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Koike, Nobuaki ,  Kase, Hiroshi ,  Nakamura, Joji ,  Shiozaki, Shizuo ,  Nonaka, Hiromi

    IPC分类号： C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/06

    摘要： Disclosed are xanthine derivatives represented by the following Formula (I):

    in which R¹, R², and R³ independently represent hydrogen or lower alkyl;
    Q¹, Q², and Q³ independently represent hydrogen, lower alkyl, lower alkoxy, or halogen;
    and X represents -COR⁴ (in which R⁴ represents hydrogen, hydroxy, lower alkyl, or lower alkoxy) or -SO₂R⁵ {in which R⁵ represents hydroxy, lower alkoxy, trifluoromethyl,

    in which R⁶ and R⁷ independently represent hydrogen, hydroxy-substituted or unsubstituted lower alkyl, aryl, or

    (in which m represents an integer of 1 to 3; and R⁸ and R⁹ independently represent hydrogen or lower alkyl), or

    (in which Y represents a single bond, oxygen, or N-R¹⁰ in which R¹⁰ represents hydrogen or lower alkyl; and n1 and n2 independently represent an integer of 1 to 3 )}, and pharmaceutically acceptable salts thereof.

    摘要翻译： 公开了由下式（I）表示的黄嘌呤衍生物：其中R 1，R 2和R 3独立地表示氢或低级烷基的 Q 1，Q 2和Q 3独立地表示氢，低级烷基，低级烷氧基或卤素; 并且X表示-COR 4（其中R 4表示氢，羟基，低级烷基或低级烷氧基）或-SO 2 R 5（其中R 5表示羟基，低级烷氧基，三氟甲基，CHEM 其中R 6和R 7独立地表示氢，羟基取代或未取代的低级烷基，芳基或（其中m表示1至3的整数;并且R 8和R 8' 或其中Y表示单键，氧或NR 1，其中R 1表示氢或低级烷基;和n1 和n2独立地表示1〜3的整数）}及其药学上可接受的盐。

    Xanthine compounds
    5.
    发明公开
    Xanthine compounds 失效
    Xanthinverbindungen。

    公开(公告)号：EP0415456A2

    公开(公告)日：1991-03-06

    申请号：EP90116791.6

    申请日：1990-08-31

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Ishii, Akio ,  Ohno, Tetsuji ,  Karasawa, Akira ,  Kubo, Kazuhiro ,  Nonaka, Hiromi

    IPC分类号： C07D473/06 ,  C07D473/08 ,  C07D473/20 ,  C07D473/22 ,  A61K31/52

    CPC分类号： C07D473/06 ,  C07D473/08 ,  C07D473/20 ,  C07D473/22

    摘要： Novel xanthine compounds represented by the following formula:
    wherein each of R¹, R² and R³ independently represents a hydrogen atom or a lower alkyl group;
    each of X¹ and X² independently represents an oxygen or sulfur atom;
    represents a single bond or a double bond;
    Y represents a single bond or an alkylene group, n represents 0 or 1, each of W¹ and W² independently represents a hydrogen atom, a lower alkyl or amino group, Z represents -CH₂-, -O-, -S- or -NH-residues; provided that when Q is
    then R¹, R² and R³ are not simultaneously methyl; and physiologically acceptable salts thereof have a diuretic effect, a renal-protecting effect and/or a bronchodilatory effect.
    The compounds are useful as a diuretic, a renal-­protecting agent and /or bronchodilator.

    摘要翻译： 由下式表示的新型黄嘌呤化合物：其中R 1，R 2和R 3各自独立地表示氢原子或低级烷基; X 1和X 2各自独立地表示氧或硫原子; 表示单键或双键; Y表示单键或亚烷基，n表示0或1，W 1和W 2各自独立地表示氢原子，低级烷基或氨基，Z表示-CH 2 - ， - O-， -S-或-NH-残基; 条件是当Q为则R 1，R 2和R 3不同时为甲基; 和其生理上可接受的盐具有利尿作用，肾保护作用和/或支气管扩张作用。 该化合物可用作利尿剂，肾保护剂和/或支气管扩张剂。

    Xanthine derivatives
    8.
    发明公开
    Xanthine derivatives 失效
    叶黄素衍。

    公开(公告)号：EP0560354A1

    公开(公告)日：1993-09-15

    申请号：EP93103926.7

    申请日：1993-03-11

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： Suzuki, Fumio ,  Shimada, Junichi ,  Karasawa, Akira ,  Mizumoto, Hideaki ,  Kase, Hiroshi ,  Nonaka, Hiromi

    IPC分类号： C07D473/06 ,  A61K31/52

    CPC分类号： C07D473/06

    摘要： A xanthine derivative of the formula (I):

    wherein R¹ and R² are the same or different and are substituted or unsubstituted alicyclic alkyl; m1 and m2 are the same or different and represent an integer of 0 to 2; and Q represents

    (in which R³ and R⁴ are the same or different and are substituted or unsubstituted alicyclic alkyl) or

    (in which n is 0 or 1, and Y is a single bond or alkylene); or a pharmaceutically acceptable salt thereof is disclosed.
    This derivative has diuretic activity and renal protecting activity.

    摘要翻译： 式（I）的黄嘌呤衍生物：其中R 1和R 2相同或不同，为取代或未取代的脂环族烷基; m1和m2相同或不同，表示0〜2的整数。 和Q表示（其中R 3和R 4相同或不同，为取代或未取代的脂环族烷基）或（其中n为0或1，Y为单键 或亚烷基）; 或其药学上可接受的盐。 该衍生物具有利尿活性和肾脏保护活性。