发明公开
EP0609588A3 Compositions of alkylbenzenes for visualization of the gastrointestinal tract
失效
用于可视化气相色谱法的烷基苯酚的组合物。
- 专利标题： Compositions of alkylbenzenes for visualization of the gastrointestinal tract
- 专利标题（中）： 用于可视化气相色谱法的烷基苯酚的组合物。
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申请号： EP93203676.7申请日： 1993-12-24
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公开(公告)号： EP0609588A3公开(公告)日： 1995-09-06
- 发明人: Josef, Kurt A., c/o Sterling Winthrop Inc. , Bacon, Edward R., c/o Sterling Winthrop Inc. , Estep, Kimberley G., c/o Sterling Winthrop Inc. , Illig, Carl, c/o Sterling Winthrop Inc. , Douty, Brent D., c/o Sterling Winthrop Inc.
- 申请人： NYCOMED IMAGING AS
- 申请人地址： Nycoveien 2, N-0485 Oslo NO
- 专利权人： NYCOMED IMAGING AS
- 当前专利权人： NYCOMED IMAGING AS
- 当前专利权人地址： Nycoveien 2, N-0485 Oslo NO
- 代理机构： Woodman, Derek
- 优先权： US13605 19930204
- 主分类号： A61K49/04
- IPC分类号： A61K49/04 ; C07C22/04 ; C07C25/02
摘要：
Disclosed are contrast agents of the formula
or pharmaceutically acceptable salts thereof,
contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
R = C 1 -C 25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxycarbonyl or lower-alkoxycarbonyloxy, (CR i R 2 )p-(CR 3 =CR 4 ) m Q, or (CR 1 R 2 )p-C=C-Q; Ri, R 2 , R 3 and R 4 are independently H, lower-alkyl, optionally substituted with halo; n is 1-5; m is 1-5; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
or pharmaceutically acceptable salts thereof,
contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein
R = C 1 -C 25 alkyl, cycloalkyl, unsaturated allyl or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxycarbonyl or lower-alkoxycarbonyloxy, (CR i R 2 )p-(CR 3 =CR 4 ) m Q, or (CR 1 R 2 )p-C=C-Q; Ri, R 2 , R 3 and R 4 are independently H, lower-alkyl, optionally substituted with halo; n is 1-5; m is 1-5; p is 1-10; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
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