发明授权
- 专利标题： MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR
- 专利标题（中）： 手段过程由类视黄醇受体调制确保两有用的链接
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申请号： EP93902758.7申请日： 1992-12-18
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公开(公告)号： EP0617614B1公开(公告)日： 1998-03-04
- 发明人: EVANS, Ronald, M. , MANGELSDORF, David, J. , HEYMAN, Richard, A. , BOEHM, Marcus, F. , EICHELE, Gregor , THALLER, Christina
- 申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , BAYLOR COLLEGE OF MEDICINE , LIGAND PHARMACEUTICALS, INC.
- 申请人地址： 10010 North Torrey Pines Road La Jolla California 92037 US
- 专利权人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES,BAYLOR COLLEGE OF MEDICINE,LIGAND PHARMACEUTICALS, INC.
- 当前专利权人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES,BAYLOR COLLEGE OF MEDICINE,LIGAND PHARMACEUTICALS, INC.
- 当前专利权人地址： 10010 North Torrey Pines Road La Jolla California 92037 US
- 代理机构： Kolb, Helga, Dr. Dipl.-Chem.
- 优先权： US809980 19911218
- 国际公布： WO9311755 19930624
- 主分类号： A61K31/07
- IPC分类号： A61K31/07
摘要：
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid receptors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoic acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discovered which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for the preparation of such retinoid receptor ligands from readily available compounds.
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