发明授权
- 专利标题： HEPATITIS E VIRUS VACCINE AND METHOD
- 专利标题（中）： 疫苗接种甲肝病毒和方法
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申请号： EP93911555.6申请日： 1993-01-15
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公开(公告)号： EP0623169B1公开(公告)日： 2003-04-02
- 发明人: REYES, Gregory R. , BRADLEY, Daniel W. , TWU, Jr-Shin , PURDY, Michael A. , TAM, Albert W. , KRAWCZYNSKI, Krzysztof Z. , YARBOUGH, Patrice O.
- 申请人： GENELABS TECHNOLOGIES, INC. , GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS
- 申请人地址： 505 Penobscot Drive Redwood City, CA 94063 US
- 专利权人： GENELABS TECHNOLOGIES, INC.,GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS
- 当前专利权人： GENELABS TECHNOLOGIES, INC.,GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS
- 当前专利权人地址： 505 Penobscot Drive Redwood City, CA 94063 US
- 代理机构： Brewster, Andrea Ruth
- 优先权： US822335 19920117; US870985 19920420
- 国际公布： WO93014208 19930722
- 主分类号： C12N15/51
- IPC分类号： C12N15/51 ; A61K39/29
摘要：
Antigen and antibody vaccine compositions effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame (2) of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.
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