专利检索 ap:("GENELABS TECHNOLOGIES, INC." OR "GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS") AND inv:"YARBOUGH, Patrice O." 第 1 页

1.

发明授权
HEPATITIS E VIRUS VACCINE AND METHOD 失效
标题翻译：疫苗接种甲肝病毒和方法

公开(公告)号：EP0623169B1

公开(公告)日：2003-04-02

申请号：EP93911555.6

申请日：1993-01-15

申请人： GENELABS TECHNOLOGIES, INC. , GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS

发明人： REYES, Gregory R. , BRADLEY, Daniel W. , TWU, Jr-Shin , PURDY, Michael A. , TAM, Albert W. , KRAWCZYNSKI, Krzysztof Z. , YARBOUGH, Patrice O.

IPC分类号： C12N15/51 , A61K39/29

CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/61 , C12N2770/28022 , C12N2770/28122 , G01N33/5767

摘要： Antigen and antibody vaccine compositions effective in preventing hepatitis E virus (HEV) infection are disclosed. The antigen composition includes a peptide corresponding to a carboxyl terminal end region of the capsid protein encoded by the second open reading frame (2) of the HEV genome. The composition is effective in preventing HEV infection after vaccination. The antibody composition contains an antibody effective to block HEV infection of human primary hepatocytes in culture.