发明公开
EP0630894A1 Propenoic acid derivatives as adenosine A1 antagonists
失效
Propensäurederivateals Adenosin A1 Antagonisten。
- 专利标题： Propenoic acid derivatives as adenosine A1 antagonists
- 专利标题（中）： Propensäurederivateals Adenosin A1 Antagonisten。
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申请号： EP94109221.5申请日： 1994-06-15
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公开(公告)号： EP0630894A1公开(公告)日： 1994-12-28
- 发明人: Daiku, Yoshiharu , Kishi, Naoya , Yoshida, Fusayo , Nomoto, Kenichi , Ogawa, Toshiaki , Takamura, Tadanobu , Nose, Koichi , Tomimatsu, Mikio , Mizuno, Masanori , Matsukura, Masayuki , Sato, Keizo , Yoneda, Naoki , Kaino, Makoto , Miyake, Kazutoshi , Negi, Shigeto , Souda, Shigeru
- 申请人： Eisai Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo JP
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo JP
- 代理机构： Herrmann-Trentepohl, Werner, Dipl.-Ing.
- 优先权： JP177278/93 19930624; JP202903/93 19930723; JP227924/93 19930821; JP237188/93 19930831
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/415 ; A61K31/44 ; C07D231/12 ; C07D233/54 ; C07D405/14 ; C07D409/14 ; C07D409/04 ; C07D405/04 ; C07D213/61 ; C07D213/38
摘要：
A novel propenoic acid derivative which exhibits adenosine A1 antagonism is defined by the general formula (I):
(wherein A represents an aromatic ring; R¹ represents aryl or the like; R², R³ and R⁴ each represent hydrogen, lower alkyl or the like; and R⁷ and R⁸ each represent lower alkyl or the like)
or a pharmacologically acceptable salt thereof.
(wherein A represents an aromatic ring; R¹ represents aryl or the like; R², R³ and R⁴ each represent hydrogen, lower alkyl or the like; and R⁷ and R⁸ each represent lower alkyl or the like)
or a pharmacologically acceptable salt thereof.
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