发明授权
- 专利标题： 27-HYDROXYRAPAMYCIN AND DERIVATIVES THEREOF
- 专利标题（中）： 27 hydroxyrapamycin及其衍生物的
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申请号： EP93919994.9申请日： 1993-08-12
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公开(公告)号： EP0655065B1公开(公告)日： 1996-12-11
- 发明人: NELSON, Frances, Christy
- 申请人： AMERICAN HOME PRODUCTS CORPORATION
- 申请人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人： AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人地址： Five Giralda Farms Madison, New Jersey 07940-0874 US
- 代理机构： Wileman, David Francis
- 优先权： US930124 19920813; US9605 19930127
- 国际公布： WO9404540 19940303
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; C07F7/18 ; A61K31/435
摘要：
This invention provides a compound of formula (I), and 27-substituted derivatives thereof which are useful as immunosuppressive, anti-inflammatory, antifungal, antitumor, and antiproliferative agents. The compound depicted by formula (I) is named 27-hydroxyrapamycin, and may also be referred to as 27-deoxo-27-hydroxyrapamycin.
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