发明公开
- 专利标题： PROTEIN TYROSINE PHOSPHATASE PTP-S31
- 专利标题（中）： 蛋白酪氨酸磷酸酶PTP-S31
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申请号： EP94911950.0申请日： 1994-03-23
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公开(公告)号： EP0690918A1公开(公告)日： 1996-01-10
- 发明人: MOLLER, Niels, P., H. , MOLLER, Karin, B. , ULLRICH, Axel
- 申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 申请人地址： Bunsenstrasse 10 D-37073 Göttingen DE
- 专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
- 当前专利权人地址： Bunsenstrasse 10 D-37073 Göttingen DE
- 代理机构： Patentanwälte Ruff, Beier, Schöndorf und Mütschele
- 优先权： US19930036210 19930323
- 国际公布： WO1994021800 19940929
- 主分类号： G01N33
- IPC分类号： G01N33 ; A61K38 ; A61K39 ; A61P43 ; C07K14 ; C07K16 ; C12N1 ; C12N9 ; C12N15 ; C12P21 ; C12Q1 ; C12R1
摘要：
A protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecules coding therefor. Included in this family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.
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