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公开(公告)号：EP4435672A1
公开(公告)日：2024-09-25
申请号：EP23162917.1
申请日：2023-03-20
发明人： SONG, Alexander , KOTTAPALLI, Sai Nikhilesh Murty , SCHLIEDER, Lennart , VOLCHKOV, Valentin , SCHÖLKOPF, Bernhard , FISCHER, Peer
IPC分类号： G06N3/067 , G06N3/0464
CPC分类号： G06N3/0675 , G06N3/0464
摘要： The present invention provides an opto-electronic computing device, comprising one or more computation modules that each comprise:
- an input layer comprising an array of photosensors for generating electrical signals based on input optical signals,
- an output layer comprising an array of light emitters for generating output optical signals,
- electronic circuitry for processing the generating electrical signals to generate driving signals for the array of light emitters, and
- an optical layer comprising an array of optical elements for modifying the optical signals,
characterized in that the device comprises one or more connection elements that pass the electrical signals from the input layer to the output board and that are oriented perpendicular to a plane of the input board.-
公开(公告)号：EP4421166A1
公开(公告)日：2024-08-28
申请号：EP23158085.3
申请日：2023-02-22
发明人： WILHELM, Jonas , HINNAH, Konstantin , LIN, Yin-Hsi , NICKEL, Lennart , HIBLOT, Julien , JOHNSSON, Kai
IPC分类号： C12N9/14
CPC分类号： C12N9/14 , C12Y308/01005 , C07K2319/7020130101
摘要： The present invention relates to improved variants of the split-HaloTag system. HaloTag is a self-labelling protein tag derived from a bacterial protein and able to covalently bind to a synthetic ligand comprising a reactive chloroalkane. HaloTag can be split into a cpHaloΔ protein and a complementing peptide which are active only when brought into close proximity. The present invention relates to improved sequences of this split-HaloTag system that are more stable and show faster kinetics than the molecules of the art.
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公开(公告)号：EP4406382A1
公开(公告)日：2024-07-31
申请号：EP22785714.1
申请日：2022-09-14
发明人： PARKIN, Stuart S.P. , YANG, See-Hun , PI, Unghwan , JEONG, Jaewoo
CPC分类号： G11C11/161 , H10N50/80 , H10N50/10 , H10N50/01
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4.发明公开
公开(公告)号：EP4368184A3
公开(公告)日：2024-07-31
申请号：EP24166495.2
申请日：2020-11-19
发明人： GIESE, Armin , SCHMIDT, Felix , WECKBECKER, Daniel , LEONOV, Andrei , RYAZANOV, Sergey , GRIESINGER, Christian , PICHLER, Bernd , HERFERT, Kristina , MAURER, Andreas , KÜBLER, Laura , BUSS, Sabrina
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , A61P25/16 , A61P25/28 , A61K31/4439 , A61K31/444 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , A61P25/16 , A61P25/28
摘要： The present invention relates to a compound represented by the general formula Ila or IIb
or a solvate or salt thereof, wherein
is selected from
and
is selected from
Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 are independently selected from CR3 and N, with the proviso that at least one of Y1, Y2, Y3, Y4, Y5, Y6, Y7 and Y8 is N and with the proviso that in the formulae la or Ib, at least one of Y1, Y3, Y4, and Y6 is N; R1 is independently selected from hydrogen, C1-4 alkyl and -(CH2)-O-P(=O)(OR)(OR), wherein C1-4 alkyl can be optionally substituted by one or more halogen; R2 is independently selected from hydrogen, halogen, and C1-4 alkyl, wherein C1-4 alkyl can be optionally substituted by one or more halogen; R is hydrogen or a cation; R3 is hydrogen; R4 and R5 are independently selected from H and C1-4 alkyl, wherein C1-4 alkyl can be optionally substituted by one or more halogen or wherein R4 and R5 together with the nitrogen atom to which they are bound form a piperazinyl ring which is substituted by one or more R6; and R6 is independently selected from halogen, C1-4 alkyl, OH and C1-4 alkoxy, wherein C1-4 alkyl and C1-4 alkoxy can be optionally substituted by one or more halogen; and Hal is halogen.-
公开(公告)号：EP3717103B1
公开(公告)日：2024-07-10
申请号：EP18807090.8
申请日：2018-11-28
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公开(公告)号：EP3941663B1
公开(公告)日：2024-06-12
申请号：EP20723436.0
申请日：2020-05-11
IPC分类号： B22F1/00 , B22F9/10 , B22D11/00 , D01D5/00 , D01D5/08 , B22D13/10 , B22D23/00 , B22D39/00 , B22F1/062 , D01F9/08
CPC分类号： B22F9/10 , D01D5/08 , B22D13/101 , B22D13/107 , B22D13/108 , B22D13/105 , B22D23/003 , B22D39/00 , D01F9/08 , B22F1/062
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公开(公告)号：EP4375293A1
公开(公告)日：2024-05-29
申请号：EP22208854.4
申请日：2022-11-22
CPC分类号： C07K2317/56920130101 , C07K2317/7620130101 , C07K2317/9220130101 , C07K2317/9420130101 , A61P31/14 , A61K2039/50520130101 , C07K2317/3320130101 , C07K16/1003
摘要： The present invention pertains in the fields of antibody technology, protein engineering, medicine, pharmacology, infection biology, virology, and medical diagnostics. More specifically, the present disclosure provides VHH antibodies that prevent cell entry of and infection by SARS-CoV-2 Omicron variants and that have been selected for potent cross-reaction and cross-neutralization between different Omicron variants, other variants of concern and the original Wuhan strain.
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公开(公告)号：EP4371951A1
公开(公告)日：2024-05-22
申请号：EP22207947.7
申请日：2022-11-17
IPC分类号： C03B37/027 , C03B37/012
CPC分类号： C03B37/0122 , C03B37/02781 , C03B2203/1420130101 , C03B2203/1620130101 , C03B2203/4220130101 , C03B2205/4020130101
摘要： Disclosed is a method of manufacturing an optical fiber, the optical fiber comprising an outer jacket and a plurality of capillaries defining a hollow core. The method comprises obtaining a fiber manufacturing intermediate product; and drawing a fiber from said fiber manufacturing intermediate product. Said drawing is such that the fiber-level capillary wall thickness of each capillary in the drawn fiber is less than 200nm and a tension applied during said drawing is larger than 20MPa.
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公开(公告)号：EP4368253A1
公开(公告)日：2024-05-15
申请号：EP22206059.2
申请日：2022-11-08
申请人： Eberhard Karls Universität Tübingen, Medizinische Fakultät , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Skokowa, Julia , ElGamacy, Mohammad
IPC分类号： A61P43/00 , C07K14/195
CPC分类号： C07K14/195 , A61P43/00 , A61K38/164
摘要： The present invention relates to a polypeptide for use as a metal-binder, a protein comprising said polypeptide, a nucleic acid molecule encoding said polypeptide or protein, an expression vector comprising the nucleic acid molecule, a recombinant host cell comprising said polypeptide, protein, nucleic acid molecule and/or expression vector, a pharmaceutical composition comprising the said polypeptide, protein, nucleic acid molecule, expression vector and/or host cell, and to a kit.
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公开(公告)号：EP4362026A1
公开(公告)日：2024-05-01
申请号：EP22203671.7
申请日：2022-10-25
发明人： Hummer, Prof. Dr. Gerhard , Sikora, Dr. Mateusz , Bülow, Sören von , Blanc, Dr. Florian , Beck, Dr. Martin , Covino, Dr. Roberto
摘要： The present invention relates to a computer-implemented method of predicting site-specific mutation activity of an antigen, said method comprising (a) providing in silico at least one three-dimensional structure of said antigen, preferably an ensemble of three-dimensional structures of said antigen; (b) providing in silico at least one three-dimensional structure of at least one antibody or fragment thereof capable of binding to or specific for said antigen, preferably an ensemble of three-dimensional structures of said antibody or fragment thereof; (c) determining in silico the accessibility of the structure(s) of (a) to the structure(s) of (b), wherein higher accessibility is indicative of higher mutation activity, in particular under selective pressure exerted by said antibody or fragment thereof; thereby predicting said site-specific mutation activity.
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