发明公开
- 专利标题： HUMAN CALCIUM CHANNEL COMPOSITIONS AND METHODS USING THEM
- 专利标题（中）： 人体钙通道及其用途
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申请号： EP94926507.0申请日： 1994-08-11
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公开(公告)号： EP0716695A1公开(公告)日： 1996-06-19
- 发明人: HARPOLD, Michael, M. , ELLIS, Steven, B. , WILLIAMS, Mark, E. , McCUE, Ann, F. , GILLESPIE, Alison
- 申请人： THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC.
- 申请人地址： 505 Coast Boulevard South, Suite 300 La Jolla, CA 92037-4641 US
- 专利权人： THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC.
- 当前专利权人： THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC.
- 当前专利权人地址： 505 Coast Boulevard South, Suite 300 La Jolla, CA 92037-4641 US
- 代理机构： Baldock, Sharon Claire, et al
- 优先权： US19930105536 19930811; US19930149097 19931105
- 国际公布： WO1995004822 19950216
- 主分类号： G01N33
- IPC分类号： G01N33 ; C07K14 ; C07K16 ; C12N1 ; C12N5 ; C12N15 ; C12P21 ; C12Q1 ; C12R1
摘要：
Isolated DNA encoding each of human calcium chanel α1-, α2-, β- and η-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the α1A-1, α1A-2, α1E-1, α1C-2, α1E-3, β3-1, β2C, β2D, β2E and β4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
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