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公开(公告)号：EP0424397B1
公开(公告)日：1996-06-19
申请号：EP89905292.2
申请日：1989-04-04
发明人： ELLIS, Steven, Bradley , WILLIAMS, Mark, E. , HARPOLD, Michael, Miller , SCHWARTZ, Arnold , SARTOR, Jean , BRENNER, Robert
IPC分类号： C07K14/435 , G01N30/00 , C12Q1/68 , C12Q1/02
CPC分类号： C07K14/705 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/564 , G01N33/68 , G01N33/6872 , G01N33/6893
摘要： Calcium channel (alpha)1-subunit and (alpha)2-subunit-encoding cDNAs, and related compositions and methods, are provided.
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公开(公告)号：EP0716695A1
公开(公告)日：1996-06-19
申请号：EP94926507.0
申请日：1994-08-11
发明人： HARPOLD, Michael, M. , ELLIS, Steven, B. , WILLIAMS, Mark, E. , McCUE, Ann, F. , GILLESPIE, Alison
CPC分类号： G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/5091
摘要： Isolated DNA encoding each of human calcium chanel α1-, α2-, β- and η-subunits, including subunits that arise as splice variants of primary transcripts, is provided. In particular DNA clones encoding each of the α1A-1, α1A-2, α1E-1, α1C-2, α1E-3, β3-1, β2C, β2D, β2E and β4 subunits of human calcium channels are provided. Cells and vectors containing the DNA, subunit specific antibodies and nucleic acid probes and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
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公开(公告)号：EP0424397A1
公开(公告)日：1991-05-02
申请号：EP89905292.0
申请日：1989-04-04
发明人： ELLIS, Steven, Bradley , WILLIAMS, Mark, E. , HARPOLD, Michael, Miller , SCHWARTZ, Arnold , SARTOR, Jean , BRENNER, Robert
CPC分类号： C07K14/705 , C12Q1/6876 , C12Q1/6897 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/564 , G01N33/68 , G01N33/6872 , G01N33/6893
摘要： Une sous-unité (alpha)1 à canal de calcium et des ADN complémentaires codant pour une sous-unité (alpha)2 ainsi que des compostions et des procédés associés sont décrits.
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