公开(公告)号：EP0957772A2

公开(公告)日：1999-11-24

申请号：EP96931360.0

申请日：1996-06-05

申请人： Quantic Biomedical Partners

发明人： HOOD, Andrew, G., III

IPC分类号： A61B17 ,  A61M5 ,  B05C17

CPC分类号： B05C17/00553 ,  A61B17/00491 ,  A61B2017/00495 ,  B01F3/0876 ,  B01F5/0268 ,  B01F13/0023 ,  B01F15/00032 ,  B01F15/00064 ,  B01F15/0087 ,  B05C17/01

摘要： The present invention provides a preparation and application device useful for mixing and dispensing a plurality of fluids, wherein the fluids must be mixed immediately prior to use. In one embodiment, the device includes two fluid delivery systems connected to a manifold having two separate fluid channels. Each fluid channel conducts fluid to a mixing chamber, from which, following mixing, the mixture of fluids is dispensed. The manifold additionally includes a gas channel having an outlet connected to one of the fluid channels, which can be used to supply a pressurized gas to the mixing chamber to expel the mixture from the chamber, reducing the likelihood that the mixture can clog the device. The invention also provides a method for preparing and dispensing a mixture of two fluids.

公开(公告)号：EP0948317A1

公开(公告)日：1999-10-13

申请号：EP97926420.0

申请日：1997-05-07

申请人： INHALE THERAPEUTIC SYSTEMS

发明人： PLATZ, Robert, M. ,  BREWER, Thomas, K. ,  BOARDMAN, Terence, D.

IPC分类号： A61K31 ,  A61K9 ,  A61K38 ,  A61M15

CPC分类号： A61K9/0075 ,  A61K9/145 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K38/28 ,  A61M15/0086

摘要： A process for preparing ultrafine powders of biological macromolecules comprises atomizing liquid solutions of the macromolecules, drying the droplets formed in the atomization step, and collecting the particles which result from drying. By properly controlling each of the atomization, drying, and collection steps, ultrafine dry powder compositions having characteristics particularly suitable for pulmonary delivery for therapeutic and other purposes may be prepared.

公开(公告)号：EP0935466A1

公开(公告)日：1999-08-18

申请号：EP97907855.0

申请日：1997-02-20

申请人： Galileo Laboratories, Inc.

发明人： MILLER, Guy ,  LOU, Lillian ,  NAKAMURA, John

IPC分类号： A23L2 ,  A23L1 ,  A61K31 ,  A61K38 ,  A61K45 ,  A61P5 ,  C07H19 ,  C12N5

CPC分类号： C07H19/16 ,  A61K31/195 ,  A61K31/70 ,  A61K45/06

摘要： Purine derivatives are provided for treatment of cellular stress, particularly hypoxia. By administering the purine derivatives by themselves or in conjunction with other compounds, particularly electron acceptor compounds and/or amino acids, the time for irreversible cellular changes, particularly mortality, can be greatly extended.

公开(公告)号：EP0927352A2

公开(公告)日：1999-07-07

申请号：EP97942670.0

申请日：1997-09-18

申请人： Aclara Biosciences, Inc.

发明人： AMIGO, M., Goretty, Alonso ,  McCORMICK, Randy, M.

IPC分类号： G01N27

CPC分类号： G01N27/44704 ,  G01N27/44752

摘要： Electrophoretic chambers having at least a region of surface modification, and methods for their fabrication, are provided. In some embodiments the subject chambers include in the region of surface modification an anchoring polymeric layer interpenetrating the surface of the chamber and an electrophoretic polymeric layer copolymerized with the anchoring polymeric layer. The subject chambers are prepared by sequentially contacting the chamber surface with a first monomer capable of interpenetrating the surface and a second monomer capable of copolymerization with the first monomer, followed by copolymerization of the first and second monomers. In other embodiments an electrophoretic polymeric layer is noncovalently bound on the surface of a rigid polymeric base material without the aid of a separate anchoring polymeric layer. The subject devices find use in any of a variety of electrophoretic applications in which entities are moved through a medium under the influence of an applied electric field.

公开(公告)号：EP0923601A2

公开(公告)日：1999-06-23

申请号：EP96928663.0

申请日：1996-08-28

申请人： PEPTOR LTD ,  YISSUM RESEARCH DEVELOPMENT COMPANY of the Hebrew University of Jerusalem

发明人： HORNIK, Vered ,  GILON, Chaim

IPC分类号： G01N33 ,  C07K1 ,  C07K5 ,  C07K7 ,  C07K14 ,  C07K17 ,  G01R31 ,  A61K38

CPC分类号： C07K7/22 ,  A61K38/00 ,  C07K1/047 ,  C07K7/56 ,  C07K14/001 ,  C07K14/6555 ,  G01R31/318541 ,  Y02P20/55

摘要： Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are Nα (φ-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these Nα (φ-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity. Further embodiments of the invention are Interleukin-6 receptor derived peptides having ring structures involving backbone cyclization.

公开(公告)号：EP0901531A1

公开(公告)日：1999-03-17

申请号：EP97924670.0

申请日：1997-05-09

申请人： SEQUENOM, INC.

发明人： KÖSTER, Hubert ,  VAN DEN BOOM, Dirk ,  RUPPERT, Andreas

IPC分类号： C12N15 ,  C12Q1

CPC分类号： C12Q1/6844 ,  C12Q1/6872 ,  C12Q2565/125 ,  C12Q2535/101 ,  C12Q2525/117 ,  C12Q2565/518 ,  C12Q2521/101

摘要： Processes and kits for simultaneously amplifying and sequencing nucleic acid molecules, and performing high throughput DNA sequencing are described.

公开(公告)号：EP0889957A1

公开(公告)日：1999-01-13

申请号：EP97906920.0

申请日：1997-02-17

申请人： GENENCOR INTERNATIONAL INC.

发明人： BOTT, Richard, R. Genencor International, Inc. ,  PAECH, Christian Genencor International, Inc. ,  WU, Shan Genencor International, Inc.

IPC分类号： C12N9 ,  C11D3 ,  C12S3 ,  D06L1 ,  D06M16 ,  D21C3 ,  D21C5

CPC分类号： C12N9/96 ,  C11D3/386 ,  C12N9/54 ,  D06M16/003 ,  D21C5/005

摘要： An enzyme multimer is provided which comprises a plurality of monomer units including a first monomer unit having enzymatic activity and a second monomer unit having enzymatic activity, wherein each of the first monomer unit and the second monomer unit comprise a cysteine residue and the cysteine residues of each monomer unit are covalently bound to each other through a disulfide bond to covalently attach the first monomer unit to the second monomer unit.

公开(公告)号：EP0871716A1

公开(公告)日：1998-10-21

申请号：EP95943520.0

申请日：1995-07-07

申请人： GENENCOR INTERNATIONAL, INC.

发明人： DEWEER, Philippe ,  AMORY, Antoine

IPC分类号： C12N9 ,  C12P19 ,  C12R1

CPC分类号： C12N9/2417 ,  C12P19/14

摘要： Novel acid-stable and thermo-stable enzymes having α-1,4 hydrolytic activity and a α-1,6 hydrolytic activity which are derived from strains of the genus Sulfolobus. These enzymes are capable of expressing high levels of α-1,4 hydrolytic activity, including the maximum α-1,4 hydrolytic activity thereof, at highly acidic pHs of between about 2.5 and about 4.5. These α-amylases are further capable of expressing high levels of α-1,4 hydrolytic activity, including the maximum α-1,4 hydrolytic activity thereof, at high temperatures of between about 90 °C and about 120 °C. Particularly disclosed herein are such enzymes which are derived from strains of the species S. acidocaldarius and, in particular, Sulfolobus acidocaldarius DSM 639. Modified starch degradation (liquefaction and saccharification) processes using these novel enzymes are also disclosed herein.

公开(公告)号：EP0868529A1

公开(公告)日：1998-10-07

申请号：EP96939373.0

申请日：1996-11-15

申请人： Ogreid, Dagfinn ,  Ulvik, Arve ,  Koornstra, Jan Jacob

发明人： Ogreid, Dagfinn ,  Ulvik, Arve ,  Koornstra, Jan Jacob

IPC分类号： C12N15 ,  C12Q1

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Method for detecting Ki-ras mutations in exon I, codon 12 to 13 in samples of tissue, tumor tissue, tissue secretions, excretions, expectorates, blood and lymph by two subsequent PCR amplifications comprising a regular PCR amplification and an allele specific amplification and wherein the identification step may comprise a Phast Gel SSCP, characterized in that by a specific selection of oligoprimers in the combination of two PCR amplifications and the Phast Gel identification or in the combination of the said regular PCR amplification and Phast Gel identification produced direct detection of the mutations is produced.

公开(公告)号：EP0868186A1

公开(公告)日：1998-10-07

申请号：EP96945220.0

申请日：1996-12-20

申请人： Alcon Laboratories, Inc.

发明人： KAPIN, Michael, A. ,  DESANTIS, Louis, M., Jr.

IPC分类号： A61K9 ,  A61K31 ,  A61P27

CPC分类号： A61K31/497 ,  A61K9/0048 ,  A61K31/551 ,  Y10S514/912 ,  Y10S514/913

摘要： Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.