发明公开
- 专利标题： NOVEL FAS PROTEIN AND METHODS OF USE THEREOF
- 专利标题（中）： Fas蛋白及使用方法
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申请号： EP95901253申请日： 1994-11-15
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公开(公告)号： EP0729300A4公开(公告)日： 1998-08-05
- 发明人: BARR PHILIP J , SHAPIRO JOHN P , KIEFER MICHAEL C
- 申请人： LXR BIOTECHNOLOGY INC
- 专利权人： LXR BIOTECHNOLOGY INC
- 当前专利权人： LXR BIOTECHNOLOGY INC
- 优先权： US15244393 1993-11-15
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A61K31/70 ; A61K38/00 ; A61K39/395 ; A61K48/00 ; A61P17/00 ; A61P35/00 ; C07H21/04 ; C07K14/705 ; C07K14/71 ; C07K14/715 ; C07K16/28 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; G01N33/53 ; A01N43/04 ; A61K35/16 ; A61K39/00 ; C07H17/00 ; C07K14/00 ; C07K14/435 ; C07K14/47 ; C07K16/00 ; C12N1/00
摘要：
The invention provides soluble forms of the Fas (Apo-1 ) protein comprising both the intracellular and extracellular domains of the full-length polypeptide. Exemplified is a naturally-occurring splice variant of the Fas gene, Fas DELTA TM, which lacks the transmembrane domain of the native antigen. DNA encoding the protein, cells expressing the recombinant DNA, and methods of using the protein and DNA are also provided.
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