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1.发明公开COMPOSITIONS CONTAINING LYSOPHOSPHATIDIC ACIDS WHICH INHIBIT APOPTOSIS AND USES THEREOF 失效LYSOPHOPHASÄURE组合物，其抑制细胞凋亡及其用途
公开(公告)号：EP1024812A1
公开(公告)日：2000-08-09
申请号：EP98911776.7
申请日：1998-03-18
发明人： BATHURST, Ian, C. , FOEHR, Matthew, W. , GODDARD, J., Graham , VMANSKY, Samuil, R. , BRADLEY, John, D. , PICKER, Donald, H.
CPC分类号： A61K31/07 , A61K9/127 , A61K31/66 , A61K45/06 , A61K2300/00
摘要： The present invention provides therapeutic compositions containing lysophosphatidic acids, methods for making the compositions, and methods of use thereof.
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2.发明公开COMPOSITIONS CONTAINING LYSOPHOSPHATIDIC ACIDS WHICH INHIBIT APOPTOSIS AND USES THEREOF 审中-公开ZUSAMMENSTELLUNGEN DIELYSOPHOSPHATIDYLSÄUREENTHALTEN WELCHE APOPTOSIS HEMMEN UND DEREN VERWENDUNGEN
公开(公告)号：EP1069895A4
公开(公告)日：2002-07-31
申请号：EP99913956
申请日：1999-03-17
发明人： GODDARD JOHN G , PICKER DONALD H , UMANSKY SAMUIL R , PRICE STEVEN , WIJKMANS JACOBUS C H M , BOYD EDWARD ANDREW , BAXTER ANTHONY DAVID
IPC分类号： A61K31/66 , A61K31/255 , A61K31/655 , C07C305/06 , C07C305/10 , C07F9/09
CPC分类号： A61K31/66
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公开(公告)号：EP1009395A4
公开(公告)日：2000-11-08
申请号：EP98906429
申请日：1998-02-17
发明人： KIEFER MICHAEL C , OSSINA NATASHA
CPC分类号： C12N15/85 , A61K38/00 , C07K14/4747 , C12N2830/00 , G01N33/5023 , G01N2510/00
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公开(公告)号：EP0711168A4
公开(公告)日：1998-04-01
申请号：EP94922680
申请日：1994-07-22
发明人： TOMEI L DAVID
IPC分类号： C07D241/08 , A61K31/495 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , A61K31/44
CPC分类号： A61K31/495
摘要： Methods are presented to prevent or delay apoptosis by administering a therapeutically effective amount of a physiologically acceptable dioxopiperazine.
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5.发明公开NOVEL APOPTOSIS-MODULATING PROTEINS, DNA ENCODING THE PROTEINS AND METHODS OF USE THEREOF 失效CDN凋亡调节蛋白，YOU编码中使用的DNA和方法
公开(公告)号：EP0731636A1
公开(公告)日：1996-09-18
申请号：EP95904808.0
申请日：1994-11-30
IPC分类号： A01K67 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1 , G01N33 , A61K38 , C12R1
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K38/00 , C07K14/4747 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences, derivatives thereof and methods of use thereof are also provided.
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公开(公告)号：EP0920539A1
公开(公告)日：1999-06-09
申请号：EP98924998.0
申请日：1998-05-29
CPC分类号： C12Q1/6888 , C12Q1/6806 , C12Q1/6879 , C12Q1/6883 , C12Q1/6886 , C12Q2600/156 , Y10T436/143333 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting the presence of specific nucleic acid sequences by analyzing urine samples for the presence of nucleic acids that have crossed the kidney barrier. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid alterations for the diagnosis of disease.
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公开(公告)号：EP0775296A1
公开(公告)日：1997-05-28
申请号：EP96915752.0
申请日：1996-05-13
发明人： TOMEI, David, L.
CPC分类号： G01J1/04 , G01J1/0488 , G01J2001/0481
摘要： The present invention is a novel apparatus that employs an integrating sphere (62) as a source of diffused light for multiple PMTs (64). The PMTs (64) are coupled to the integrating sphere (62) to receive diffused light from the integrating sphere (62). An optional faceplate (66) may be employed at the input port of the integrating sphere (62) in order to select certain characteristics of the light according to the characteristics of the faceplate (66).
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8.发明公开A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM 失效POLLENPROTEINASEN新系列，其使用方法和衍生组合
公开(公告)号：EP0705435A1
公开(公告)日：1996-04-10
申请号：EP94921321.0
申请日：1994-06-17
发明人： TRAVIS, James , BARR, Philip, J.
IPC分类号： G01N33 , A61K36 , A61K38 , A61P37 , A61P43 , C07H21 , C12N1 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K39 , C12R1
摘要： A novel family of proteins has been identified. The proteins are derived from allergenic pollens and exhibit serine-proteinase-like activity. The proteins have a molecular weight of about 85-95 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis; and a molecular weight of about 67 kD as determined by Fast Protein Liquid Chromatography. The proteins are resistant to inhibition by α-2-macroglobulin, α-1-proteinase inhibitor, trypsin inhibitors and are sensitive to inhibition by phenyl methane sulfonyl fluoride, difluorophenol, benzamidine, antipain, leupeptin and tosyl-L-lysine chloromethyl ketone.
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9.发明公开METHODS OF IDENTIFYING POTENTIALLY THERAPEUTICALLY EFFECTIVE AGENTS AND CELL STRAINS FOR USE THEREIN 失效方法能够识别潜在的治疗性的有效手段及适宜达尔富尔细胞系
公开(公告)号：EP0703990A1
公开(公告)日：1996-04-03
申请号：EP94916006.0
申请日：1994-04-29
发明人： TOMEI, L., David
CPC分类号： G01N33/5011 , C12N5/0693 , C12N2500/20 , C12N2503/02 , G01N33/5008 , G01N33/5014 , G01N33/5017 , G01N2500/10 , G01N2510/00
摘要： The present invention is to a method of screening agents for potential therapeutic efficacy. The method comprises exposing a cell strain that is sensitive to known apoptotic agents to said apoptotic agents and to a potential therapeutic agent. The cell strain is then cultured and cells are removed that display diminished adherence. The remaining, adherent, cells are then incubated in the presence of a proteinase to release proteinase sensitive cells. The proteinase sensitive cells are removed to yield proteinase resistant cells and the proteinase sensitive cells are counted. The proteinase resistant cells are then collected and counted. The agent is determined to have potential therapeutic efficacy if the ratio of proteinase sensitive cells to proteinase resistant cells changes relative to a control as a result of the presence of the agent.
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公开(公告)号：EP1009395A1
公开(公告)日：2000-06-21
申请号：EP98906429.0
申请日：1998-02-17
CPC分类号： C12N15/85 , A61K38/00 , C07K14/4747 , C12N2830/00 , G01N33/5023 , G01N2510/00
摘要： The present invention provides polynucleotides which regulate the expression of a gene involved in apoptosis. Also provided are methods for identifying agents that modulate expression of a gene involved in apoptosis.
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