发明授权
EP0752988B1 DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE ANTAGONISTES DES RECEPTEURS AMPA ET NMDA
失效
-5H-茚并[1,2-B]的AMPA和NMDA受体的吡嗪-2,3-二酮衍生物拮抗剂
- 专利标题： DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE ANTAGONISTES DES RECEPTEURS AMPA ET NMDA
- 专利标题（英）： 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS
- 专利标题（中）： -5H-茚并[1,2-B]的AMPA和NMDA受体的吡嗪-2,3-二酮衍生物拮抗剂
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申请号： EP95914405.6申请日： 1995-03-23
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公开(公告)号： EP0752988B1公开(公告)日： 1999-05-26
- 发明人: ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MAGNANI, Serge , RIBEILL, Yves
- 申请人： RHONE-POULENC RORER S.A.
- 申请人地址： 20, avenue Raymond Aron 92160 Antony FR
- 专利权人： RHONE-POULENC RORER S.A.
- 当前专利权人： RHONE-POULENC RORER S.A.
- 当前专利权人地址： 20, avenue Raymond Aron 92160 Antony FR
- 代理机构： Savina, Jacques
- 优先权： FR9403583 19940328
- 国际公布： WO9526342 19951005
- 主分类号： C07D241/38
- IPC分类号： C07D241/38 ; C07D487/04 ; A61K31/495
摘要：
Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, the preparation thereof and drugs containing same, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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