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1.发明公开DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效5H茚并[1,2-B]吡嗪-2,3-二酮衍生物，生产和药物含有它们
公开(公告)号：EP0752988A1
公开(公告)日：1997-01-15
申请号：EP95914405.0
申请日：1995-03-23
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MAGNANI, Serge , RIBEILL, Yves
CPC分类号： C07D241/38 , C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, the preparation thereof and drugs containing same, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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公开(公告)号：EP0643711A1
公开(公告)日：1995-03-22
申请号：EP93902350.0
申请日：1992-12-18
IPC分类号： C07D471
CPC分类号： C07D471/04
摘要： A method for preparing enantiomers of the product of formula (I) by hydrolyzing a diastereoisomeric acetal of general formula (II), wherein R1, R2, R3 and R4 are chiral diol residues. The dextrorotatory isomer of the product of formula (I) has anxiety-relieving, hypnotic, anticonvulsant, antiepileptic and muscle relaxant properties.
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3.发明授权DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE ANTAGONISTES DES RECEPTEURS AMPA ET NMDA 失效-5H-茚并[1,2-B]的AMPA和NMDA受体的吡嗪-2,3-二酮衍生物拮抗剂
公开(公告)号：EP0752988B1
公开(公告)日：1999-05-26
申请号：EP95914405.6
申请日：1995-03-23
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MAGNANI, Serge , RIBEILL, Yves
IPC分类号： C07D241/38 , C07D487/04 , A61K31/495
CPC分类号： C07D241/38 , C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, the preparation thereof and drugs containing same, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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4.发明公开DERIVES D'ACIDE IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIQUE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效咪唑并[1,2-α]茚并[1,2-E]吡嗪-2-羧酸衍生物，它们的生产和药物含有它们
公开(公告)号：EP0772615A1
公开(公告)日：1997-05-14
申请号：EP95925891.0
申请日：1995-07-17
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
CPC分类号： C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, preparation thereof and drugs containing said compounds.
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5.发明授权SPIRO[HETEROCYCLE-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE]-4'-ONES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效螺[HETEROZYCLISCHE咪唑并[1,2-α] [1,2-e]吡嗪将] -4'- ONE，生产和药物含有它们
公开(公告)号：EP0789699B1
公开(公告)日：1999-03-17
申请号：EP95936624.6
申请日：1995-10-30
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
IPC分类号： C07D487/20 , C07D471/20
CPC分类号： C07D471/20 , C07D487/20
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6.发明公开DERIVES DE 4-HYDROXY-3-PHENYL-INDENO(1,2-B)PYRIDINE-2(1H)-ONE COMME NMDA ANTAGONISTES 失效4-羟基-3-苯基茚并（1,2-B）吡啶-2（1H） - 酮衍生物AS NMDA拮抗剂
公开(公告)号：EP0772612A1
公开(公告)日：1997-05-14
申请号：EP95925892.0
申请日：1995-07-17
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
CPC分类号： C07D495/04 , C07D221/16
摘要： Derivatives of formula (I), wherein R is a methylene radical, N-alk, NH or an oxygen or sulphur atom, R1 and R2, which are the same or different, are a hydrogen or halogen atom or a hydroxy, alkoxy, alkyl, nitro, amino, monoalkylamino, dialkylamino, cyano, polyfluoroalkyl, polyfluoroalkoxy or phenoxy radical, R3 and R4, which are the same or different, are a hydrogen or halogen atom or an alkyl radical; tautomeric forms thereof, salts thereof, preparation thereof and drugs containing said derivatives.
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7.发明公开DERIVES D'IMIDAZO[1,2-a]PYRAZINE-4-ONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效IMIDAZO¬1,2-吡嗪-4酮衍生物，它们的制备和药物含有它们的
公开(公告)号：EP0752994A1
公开(公告)日：1997-01-15
申请号：EP95914407.0
申请日：1995-03-23
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
IPC分类号： A61K31 , A61P9 , A61P25 , A61P29 , A61P31 , A61P39 , C07D233 , C07D471 , C07D487 , C07D491 , C07D495
CPC分类号： C07D471/14 , C07D487/04 , C07D491/14 , C07D495/14
摘要： Compounds of formula (I), wherein ring A is selected from rings 1, 2 and 3, wherein R is a CH2 radical or a sulphur, oxygen or nitrogen atom substituted by an alkyl radical, salts thereof, preparation thereof and drugs containing same. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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8.发明公开SPIRO HETEROCYCLE-IMIDAZO(1,2-a]INDENO(1,2-e]PYRAZINE]-4'-ONES, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效螺[HETEROZYCLISCHE咪唑并[1,2-α]茚并[1,2-e]吡嗪将）-4'- ONE，它们的生产和药物含有它们
公开(公告)号：EP0789699A1
公开(公告)日：1997-08-20
申请号：EP95936624.0
申请日：1995-10-30
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
CPC分类号： C07D471/20 , C07D487/20
摘要： Compounds of formula (I), wherein R3 and R4, taken together with the carbon atom to which they are attached, form (a) a 2- or 3-pyrrolidine ring, a 2- or 4-piperidine ring or a 2-azacycloheptane ring, said rings being optionally substituted at the nitrogen atom by an alkyl radical, -CHO, -COOR11, -CO-alk-COOR6, -CO-alk-NR6R12, -CO-alk-CONR6R8, -CO-COOR6, -CO-CH2-O-CH2-COOR6, -CO-CH2-S-CH2-COOR6, -CO-CH=CH-COOR6, -CO-alk, -CO-Ar'. -CO-alk-Ar', -CO-NH-Ar', -CO-NH-alk-Ar', -CO-Het, -CO-alk-Het, -CO-NH-Het, -CO-NH-alk-Het, -CO-NH2, -CO-NH-alk, -CO-N(alk)alk', -CS-NH2, -CS-NH-alk, -CS-NH-Ar', -CS-NH-Het, -alk-Het, -alk-NR6R8, -alk-COOR6, -alk-CO-NR6R8, -alk-Ar', -SO2-alk, -SO2-Ar or -CO-cycloalkyl, where the cycloalkyl is optionally 2-substituted by a carboxy radical; or (b) a 2-pyrrolidine-5-one ring. The compounds of formula (I) have useful pharmacological properties and are α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and especially NMDA receptor glycine modulation site ligands.
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9.发明授权DERIVE DE L'ISOINDOLINONE, SA PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LE CONTIENNENT 失效异吲哚啉衍生物生产和含有药物成分的要求。
公开(公告)号：EP0625153B1
公开(公告)日：1995-09-06
申请号：EP93904153.9
申请日：1993-02-04
发明人： BARREAU, Michel , CHEVE, Michel , DUBROEUCQ, Marie-Christine , DUTRUC-ROSSET, Gilles , MANFRE, Franco
IPC分类号： C07D471/04 , A61K31/44 , B01D15/08
CPC分类号： C07D471/04
摘要： A novel isoindolinone derivative of formula (I) in racemic form or in the form of its enantiomers; preparation thereof; and pharmaceutical compositions containing same. The novel product of formula (I) is useful in therapeutics as an anxiety-relieving, hypnotic, anticonvulsant, antiepileptic and muscle relaxant agent.
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10.发明授权DERIVES D'ACIDE IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIQUE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效咪唑并[1,2-α]茚并[1,2-E]吡嗪-2-羧酸衍生物，它们的生产和药物含有它们
公开(公告)号：EP0772615B1
公开(公告)日：1999-09-22
申请号：EP95925891.4
申请日：1995-07-17
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MIGNANI, Serge , RIBEILL, Yves
IPC分类号： C07D487/04 , C07D487/14 , A61K31/50
CPC分类号： C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, preparation thereof and drugs containing said compounds.
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