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1.发明授权DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE ANTAGONISTES DES RECEPTEURS AMPA ET NMDA 失效-5H-茚并[1,2-B]的AMPA和NMDA受体的吡嗪-2,3-二酮衍生物拮抗剂
公开(公告)号：EP0752988B1
公开(公告)日：1999-05-26
申请号：EP95914405.6
申请日：1995-03-23
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MAGNANI, Serge , RIBEILL, Yves
IPC分类号： C07D241/38 , C07D487/04 , A61K31/495
CPC分类号： C07D241/38 , C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, the preparation thereof and drugs containing same, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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2.发明公开DERIVES DE 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE, LEUR PREPARATION ET LES MEDICAMENTS LES CONTENANT 失效5H茚并[1,2-B]吡嗪-2,3-二酮衍生物，生产和药物含有它们
公开(公告)号：EP0752988A1
公开(公告)日：1997-01-15
申请号：EP95914405.0
申请日：1995-03-23
发明人： ALOUP, Jean-Claude , AUDIAU, François , BARREAU, Michel , DAMOUR, Dominique , GENEVOIS-BORELLA, Arielle , JIMONET, Patrick , MAGNANI, Serge , RIBEILL, Yves
CPC分类号： C07D241/38 , C07D487/04
摘要： Compounds of formula (I), wherein R, R1, R2 and R3 are as defined in the description, salts thereof, the preparation thereof and drugs containing same, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.
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