发明授权
EP0763059B1 RECOMBINANT ALLERGEN, FRAGMENTS THEREOF, CORRESPONDING RECOMBINANT DNA MOLECULES, VECTORS AND HOSTS CONTAINING THE DNA MOLECULES, DIAGNOSTIC AND THERAPEUTIC USES OF SAID ALLERGENS AND FRAGMENTS
失效
重组变应原，及其片段和相应的DNA分子，载体，而这个DNA分子含主机和DIGNOSTISCHE和治疗用途所述碎片和过敏原
- 专利标题： RECOMBINANT ALLERGEN, FRAGMENTS THEREOF, CORRESPONDING RECOMBINANT DNA MOLECULES, VECTORS AND HOSTS CONTAINING THE DNA MOLECULES, DIAGNOSTIC AND THERAPEUTIC USES OF SAID ALLERGENS AND FRAGMENTS
- 专利标题（中）： 重组变应原，及其片段和相应的DNA分子，载体，而这个DNA分子含主机和DIGNOSTISCHE和治疗用途所述碎片和过敏原
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申请号： EP95922855.2申请日： 1995-06-14
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公开(公告)号： EP0763059B1公开(公告)日： 2007-08-29
- 发明人: BALL, Tanja , VRTALA, Susanne , SPERR, Wolfgang , VALENT, Peter , SUSANI, Markus , KRAFT, Dietrich , VALENTA, Rudolf , LAFFER, Sylvia
- 申请人： Phadia AB
- 申请人地址： Box 6460 751 37 Uppsala SE
- 专利权人： Phadia AB
- 当前专利权人： Phadia AB
- 当前专利权人地址： Box 6460 751 37 Uppsala SE
- 代理机构： Lindgren, Anders
- 优先权： SE9402089 19940614
- 国际公布： WO1995034578 19951221
- 主分类号： C07K14/415
- IPC分类号： C07K14/415 ; C12N15/29 ; A61K39/36 ; C07K14/735
摘要：
A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2 and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2. Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.
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