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    ANALYSIS OF ANTIBODIES
    1.
    发明授权
    ANALYSIS OF ANTIBODIES 有权

    公开(公告)号：EP3084439B1

    公开(公告)日：2018-09-19

    申请号：EP14824416.3

    申请日：2014-12-16

    申请人： Phadia AB

    发明人： MOVÉRARE, Robert ,  ERIKSSON, Camilla ,  VENEMALM, Lennart

    IPC分类号： G01N33/543 ,  G01N33/68

    CPC分类号： G01N33/6854 ,  G01N33/54353 ,  G01N33/94

    摘要： The present invention relates to a method which may be used for the analysis of endogenously formed antibodies such as anti-drug antibodies (ADAs) or rheumatoid factor (RF) in a solution, which method comprises (a) contacting the solution with a solid phase to which e.g. IgG molecule(s) have been attached; (b) allowing the ADAs or RF to bind specifically to the attached molecule(s); (c) adding a labeled isotype-specific reagent capable of binding ADAs or RF; (d) removing any excess of reagent; and (f) detecting the label bound or unbound to determine directly or indirectly the presence or concentration of ADAs in the solution. The molecule(s) have been attached to the solid phase via a linker, which may be an organic molecule, an amino acid, a peptide, a protein a molecule of protein origin, a monosaccharide, an oligosaccharide or a polysaccharide. The method according to the invention may be used e.g. as an immunoassay for making clinical decisions in patient care, as well as in the development of new drugs.

    METHOD FOR INDICATING A PRESENCE OR NON-PRESENCE OF AGGRESSIVE PROSTATE CANCER
    2.
    发明公开
    METHOD FOR INDICATING A PRESENCE OR NON-PRESENCE OF AGGRESSIVE PROSTATE CANCER 审中-公开

    公开(公告)号：EP3327146A1

    公开(公告)日：2018-05-30

    申请号：EP17210720.3

    申请日：2013-11-20

    申请人： Phadia AB

    发明人： EKLUND, Martin ,  GRÖNBERG, Henrik

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： G06F19/18 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57434

    摘要： The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to determine if it is likely that the patient suffers from aggressive prostate cancer. The present invention is particularly applicable only for patients having a body mass index value greater than 25.

    DEVICE FOR DETECTION OF WHEN A TEST PROBE GETS INTO CONTACT WITH A LIQUID SURFACE
    9.
    发明授权
    DEVICE FOR DETECTION OF WHEN A TEST PROBE GETS INTO CONTACT WITH A LIQUID SURFACE 失效
    设备涵盖了测试探针时由液体表面

    公开(公告)号：EP0927339B1

    公开(公告)日：2007-11-07

    申请号：EP97943251.5

    申请日：1997-09-15

    申请人： Phadia AB

    发明人： LJUNG, Arne ,  KIVINEEME, Juhan

    IPC分类号： G01F23/22

    CPC分类号： G01N35/1009 ,  G01F23/244 ,  G01F23/266 ,  G01N2035/1025

    摘要： At a device for detection of when a test probe (1) of conducting material gets into contact with a liquid surface, the test probe (1) is electrically screened by means of a screen (2), isolated from the test probe, with a part of the test probe (1) projecting in front of the screen (2). The test probe (1) is connected on one hand to a first alternating voltage source (U1) via a first impedance (Z1) and on the other to one of the inputs of a differential amplifier (3). The screen (2) is connected on one hand to a second alternating voltage source (U2) via a second impedance (Z2) and on the other to the other input of the differential amplifier (3). The output of the differential amplifier (3) is connected on one hand to one of the inputs of a first multiplier (4), whose other input is connected to a third alternating voltage source (U3), and on the other to one of the inputs of a second multiplicator (5), whose other input is connected to a fourth alternating voltage source (U4). A signal processing unit (6) is connected to the outputs of the multiplicators (4, 5) and disposed to, based on the output signals of the multiplicators (4, 5), derive on one hand a first signal, representing the resistive load of the test probe (1), and on the other a second signal, representing the capacitive load of the test probe (2), and to provide a signal when the resistive load is low, contemporarily as the capacitive load is high, as an indication of that the test probe (1) has got into contact with the liquid surface.

    PROGNOSTIC METHOD FOR INDIVIDUALS WITH PROSTATE CANCER
    10.
    发明授权
    PROGNOSTIC METHOD FOR INDIVIDUALS WITH PROSTATE CANCER 有权

    公开(公告)号：EP2922970B1

    公开(公告)日：2018-08-08

    申请号：EP13799501.5

    申请日：2013-11-20

    申请人： Phadia AB

    发明人： GRÖNBERG, Henrik ,  EKLUND, Martin

    IPC分类号： C12Q1/6886

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/16 ,  G06F19/24

    摘要： The present invention relates generally to the detection and identification of various forms of genetic markers, and various forms of proteins, which have the potential utility as diagnostic markers. By determining the level of a plurality of biomarkers and genetic markers in a patient sample, and combining the obtained values according to a predefined formula, it is possible to forecast if it is likely that the prostate cancer patient will require active therapy like radiation therapy or surgery. A method based on a redundantly designed combination of data is disclosed for estimating if prostate cancer is aggressive or indolent. Said method combines SNP data to form a composite value, wherein at least 5% of the SNPs can be disregarded.