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1.发明授权RECOMBINANT ALLERGEN, FRAGMENTS THEREOF, CORRESPONDING RECOMBINANT DNA MOLECULES, VECTORS AND HOSTS CONTAINING THE DNA MOLECULES, DIAGNOSTIC AND THERAPEUTIC USES OF SAID ALLERGENS AND FRAGMENTS 失效重组变应原，及其片段和相应的DNA分子，载体，而这个DNA分子含主机和DIGNOSTISCHE和治疗用途所述碎片和过敏原
公开(公告)号：EP0763059B1
公开(公告)日：2007-08-29
申请号：EP95922855.2
申请日：1995-06-14
申请人： Phadia AB
发明人： BALL, Tanja , VRTALA, Susanne , SPERR, Wolfgang , VALENT, Peter , SUSANI, Markus , KRAFT, Dietrich , VALENTA, Rudolf , LAFFER, Sylvia
IPC分类号： C07K14/415 , C12N15/29 , A61K39/36 , C07K14/735
CPC分类号： C07K14/415 , A61K38/00 , C07K2319/00
摘要： A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2 and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in figure 2. Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.
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2.发明授权RECOMBINANT ALLERGEN, FRAGMENTS THEREOF, CORRESPONDING RECOMBINANT DNA MOLECULES, VECTORS AND HOSTS CONTAINING THE DNA MOLECULES, DIAGNOSTIC AND THERAPEUTIC USES OF SAID ALLERGENS AND FRAGMENTS 失效重组变应原，及其片段和相应的DNA分子，载体，而这个DNA分子含主机和DIGNOSTISCHE和治疗用途所述碎片和过敏原
公开(公告)号：EP0763059B2
公开(公告)日：2010-07-28
申请号：EP95922855.2
申请日：1995-06-14
申请人： Phadia AB
发明人： BALL, Tanja , VRTALA, Susanne , SPERR, Wolfgang , VALENT, Peter , SUSANI, Markus , KRAFT, Dietrich , VALENTA, Rudolf , LAFFER, Sylvia
IPC分类号： C07K14/415 , C12N15/29 , A61K39/36 , C07K14/735
CPC分类号： C07K14/415 , A61K38/00 , C07K2319/00
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